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Journal of Clinical Microbiology
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Research Article

New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test.

R Kappe, A Schulze-Berge
R Kappe
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A Schulze-Berge
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DOI: 
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ABSTRACT

The Pastorex Aspergillus antigen test for detection of Aspergillus galactomannan antigen in the sera of patients with invasive aspergillosis is used in many clinical laboratories. A serum sample contaminated with Penicillium chrysogenum gave a strongly positive reaction (1:128) which was heat stable, was not eliminated by pronase treatment, and was not detected by a normal rabbit globulin control. This observation was shown to be due to cross-reactions of the monoclonal antibody EB-A2 used by the kit with several airborne fungi likely to contaminate serum samples, including Penicillium chrysogenum, Cladosporium herbarum, Acremonium species, Alternaria alternata, Fusarium oxysporum, Wangiella dermatitidis, and Rhodotorula rubra.

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New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test.
R Kappe, A Schulze-Berge
Journal of Clinical Microbiology Sep 1993, 31 (9) 2489-2490; DOI:

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New cause for false-positive results with the Pastorex Aspergillus antigen latex agglutination test.
R Kappe, A Schulze-Berge
Journal of Clinical Microbiology Sep 1993, 31 (9) 2489-2490; DOI:
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