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Chlamydiology and Rickettsiology

Performance of the Gen-Probe AMPLIFIED Chlamydia Trachomatis Assay in Detecting Chlamydia trachomatis in Endocervical and Urine Specimens from Women and Urethral and Urine Specimens from Men Attending Sexually Transmitted Disease and Family Planning Clinics

Dennis V. Ferrero, Holly N. Meyers, Diane E. Schultz, Stephen A. Willis
Dennis V. Ferrero
San Joaquin County Regional Public Health Laboratory, Stockton, California
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Holly N. Meyers
San Joaquin County Regional Public Health Laboratory, Stockton, California
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Diane E. Schultz
San Joaquin County Regional Public Health Laboratory, Stockton, California
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Stephen A. Willis
San Joaquin County Regional Public Health Laboratory, Stockton, California
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DOI: 10.1128/JCM.36.11.3230-3233.1998
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  • Table 1.

    Comparison of cell culture and AMP CT results forC. trachomatis from swab and urine specimens from men and women before and after resolution by discrepant analysis

    Time of analysis and sample typeNo. of specimens
    Culture of swabsAMP CT of swabs and urineTotal
    PositiveNegativePositiveNegative
    Initial resultsa
     Urine specimens
      Male1817523170193
      Female2658132575607
     Swab specimens
      Male2118832177209
      Female3068739678717
    After discrepant analysisb
     Urine specimens
      Male2616723170193
      Female3157632575607
     Swab specimens
      Male3217732177209
      Female3967839678717
    • ↵a Specimens determined to be positive or negative for C. trachomatis by culture or AMP CT.

    • ↵b Specimens determined to be positive or negative for C. trachomatis by culture, repeat culture, DFA assay, and/or supplementary TMA testing.

  • Table 2.

    Sensitivity, specificity, prevalence, PPV, and NPV for AMP CT before and after resolution by discrepant analysis

    Time of analysis and sample typeSensitivity (%)Specificity (%)Prevalence (%)Predictive value (%)
    PositiveNegative
    Initial results
     Urine specimens
      Male83.395.415.376.699.9
      Female92.398.65.472.899.9
     Swab specimens
      Male100.094.115.375.4100.0
      Female100.098.75.481.5100.0
    After discrepant analysis
     Urine specimens
      Male88.5100.015.3100.099.9
      Female93.599.55.488.499.9
     Combined results91.299.67.795.099.9
     Swab specimens
      Male100.0100.015.3100.0100.0
      Female100.0100.05.4100.0100.0
     Combined results100.0100.07.7100.0100.0
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Performance of the Gen-Probe AMPLIFIED Chlamydia Trachomatis Assay in Detecting Chlamydia trachomatis in Endocervical and Urine Specimens from Women and Urethral and Urine Specimens from Men Attending Sexually Transmitted Disease and Family Planning Clinics
Dennis V. Ferrero, Holly N. Meyers, Diane E. Schultz, Stephen A. Willis
Journal of Clinical Microbiology Nov 1998, 36 (11) 3230-3233; DOI: 10.1128/JCM.36.11.3230-3233.1998

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Performance of the Gen-Probe AMPLIFIED Chlamydia Trachomatis Assay in Detecting Chlamydia trachomatis in Endocervical and Urine Specimens from Women and Urethral and Urine Specimens from Men Attending Sexually Transmitted Disease and Family Planning Clin…
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Performance of the Gen-Probe AMPLIFIED Chlamydia Trachomatis Assay in Detecting Chlamydia trachomatis in Endocervical and Urine Specimens from Women and Urethral and Urine Specimens from Men Attending Sexually Transmitted Disease and Family Planning Clinics
Dennis V. Ferrero, Holly N. Meyers, Diane E. Schultz, Stephen A. Willis
Journal of Clinical Microbiology Nov 1998, 36 (11) 3230-3233; DOI: 10.1128/JCM.36.11.3230-3233.1998
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