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Journal of Clinical Microbiology
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Virology

Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection

Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Giuseppe Gerna
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Maurizio Zavattoni
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Elena Percivalle
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Paolo Grossi
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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Maria Torsellini
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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M. Grazia Revello
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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DOI: 10.1128/JCM.36.4.1113-1116.1998
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ABSTRACT

In 7 of 18 solid-organ transplant recipients with primary human cytomegalovirus (HCMV) infection, HCMV antigenemia levels were unexpectedly found to rise significantly (P = 0.018) during a mean time of 7.3 ± 3.2 days after initiation of specific antiviral treatment, whereas corresponding levels of viremia dropped significantly (P = 0.043). Thus, shifting to an alternative antiviral drug based solely on increasing antigenemia levels is not justified in this group of patients.

  • Copyright © 1998 American Society for Microbiology
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Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection
Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Journal of Clinical Microbiology Apr 1998, 36 (4) 1113-1116; DOI: 10.1128/JCM.36.4.1113-1116.1998

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Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection
Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Journal of Clinical Microbiology Apr 1998, 36 (4) 1113-1116; DOI: 10.1128/JCM.36.4.1113-1116.1998
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KEYWORDS

Antigens, Viral
Antiviral Agents
cytomegalovirus
Cytomegalovirus Infections
Organ Transplantation

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