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Virology

Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection

Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Giuseppe Gerna
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Maurizio Zavattoni
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Elena Percivalle
Viral Diagnostic Service, IRCCS Policlinico San Matteo, and
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Paolo Grossi
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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Maria Torsellini
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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M. Grazia Revello
Institute of Infectious Diseases, University of Pavia, Pavia, Italy
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DOI: 10.1128/JCM.36.4.1113-1116.1998
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    Fig. 1.

    Distribution of HCMV viremia, antigenemia, and L-DNAemia levels in a group of 18 solid-organ transplant recipients with primary HCMV infection, including 11 with normal and 7 with delayed responses to antiviral treatment. Bars indicate median values. B, values before onset of treatment. A, reported antigenemia values referring to the earliest blood sample showing ≥90% progressive reduction in antigenemia level after onset of treatment; viremia and L-DNAemia were determined with the same sample. A′, reported antigenemia values referring to peaks of increasing antigenemia levels detected after onset of treatment; viremia and L-DNAemia values were determined with the same blood samples.

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  • Table 1.

    Correlation of onset of antiviral treatment and antigenemia, viremia, and L-DNAemia level in solid-organ transplant patients with primary HCMV infection

    PatientType of transplantSexaAge (yr)Days after transplantHCMV quantitation in bloodAntiviral drug (days of administration)bOnset of treatment after 1st positive antigenemia (day)HCMV-related clinical symptomsc
    ViremiaAntigenemiaL-DNAemia
    5HTM373000
    10000
    170010
    240012
    2835147
    314261,122
    33155127>10,000
    35184390>10,000G (35–48)7+
    38085114
    40025185
    420610
    4701NDd
    10HTM182000
    90011
    160018
    183217562
    2303379
    262353ND
    30ND1421,995G (31–44)13+
    37010251
    400020
    12HTM2716000
    190419
    2670180194
    30136400>10,000
    33110300>10,000F (34–48)15+
    37035
    16SLTM46200010
    2308208
    2530125316G (25–33)2−
    270323225
    300400141
    325390105
    343360101F (34–47)
    3601011
    39055
    410012
    44000
    22SLTF2420000
    25ND1310
    3206637G (26–41)1−
    350109256
    390235
    41085
    50015
    55005
    26HTM3021000
    28000
    33005
    3555141
    40028742G (36–57)1−
    470225
    54025
    57000
    • ↵a M, male; F, female.

    • ↵b G, ganciclovir; F, foscarnet.

    • ↵c +, presence of clinical symptoms; −, absence of clinical symptoms.

    • ↵d ND, not determined.

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Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection
Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Journal of Clinical Microbiology Apr 1998, 36 (4) 1113-1116; DOI: 10.1128/JCM.36.4.1113-1116.1998

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Rising Levels of Human Cytomegalovirus (HCMV) Antigenemia during Initial Antiviral Treatment of Solid-Organ Transplant Recipients with Primary HCMV Infection
Giuseppe Gerna, Maurizio Zavattoni, Elena Percivalle, Paolo Grossi, Maria Torsellini, M. Grazia Revello
Journal of Clinical Microbiology Apr 1998, 36 (4) 1113-1116; DOI: 10.1128/JCM.36.4.1113-1116.1998
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KEYWORDS

Antigens, Viral
Antiviral Agents
cytomegalovirus
Cytomegalovirus Infections
Organ Transplantation

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