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Virology

Antigenic and Genomic Diversity of Human Rotavirus VP4 in Two Consecutive Epidemic Seasons in Mexico

Luis Padilla-Noriega, Martha Méndez-Toss, Griselda Menchaca, Juan F. Contreras, Pedro Romero-Guido, Fernando I. Puerto, Héctor Guiscafré, Felipe Mota, Ismael Herrera, Roberto Cedillo, Onofre Muñoz, Juan Calva, María de Lourdes Guerrero, Barbara S. Coulson, Harry B. Greenberg, Susana López, Carlos F. Arias
Luis Padilla-Noriega
Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,
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Martha Méndez-Toss
Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,
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Griselda Menchaca
Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León,
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Juan F. Contreras
Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León,
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Pedro Romero-Guido
Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,
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Fernando I. Puerto
Centro de Investigaciones Regionales “Hideyo Noguchi,” Universidad Autónoma de Yucatán, Mérida, Yucatán,
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Héctor Guiscafré
Instituto Mexicano del Seguro Social and
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Felipe Mota
Unidad de Rehidratación Oral, Hospital Infantil de México, Mexico City,
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Ismael Herrera
Facultad de Medicina, Universidad Autónoma de San Luis Potosı́, San Luis Potosı́, San Luis Potosı́, and
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Roberto Cedillo
Instituto Mexicano del Seguro Social and
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Onofre Muñoz
Instituto Mexicano del Seguro Social and
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Juan Calva
Instituto Nacional de la Nutrición Salvador Zubirán, Mexico;
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María de Lourdes Guerrero
Instituto Nacional de la Nutrición Salvador Zubirán, Mexico;
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Barbara S. Coulson
University of Melbourne, Parkville, Victoria, Australiaand
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Harry B. Greenberg
Stanford University, Stanford, California
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Susana López
Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,
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Carlos F. Arias
Instituto de Biotecnologı́a, Universidad Nacional Autónoma de México, Cuernavaca, Morelos,
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DOI: 10.1128/JCM.36.6.1688-1692.1998
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ABSTRACT

In the present investigation we characterized the antigenic diversity of the VP4 and VP7 proteins in 309 and 261 human rotavirus strains isolated during two consecutive epidemic seasons, respectively, in three different regions of Mexico. G3 was found to be the prevalent VP7 serotype during the first year, being superseded by serotype G1 strains during the second season. To antigenically characterize the VP4 protein of the strains isolated, we used five neutralizing monoclonal antibodies (MAbs) which showed specificity for VP4 serotypes P1A, P1B, and P2 in earlier studies. Eight different patterns of reactivity with these MAbs were found, and the prevalence of three of these patterns varied from one season to the next. The P genotype of a subset of 52 samples was determined by PCR. Among the strains characterized as genotype P[4] and P[8] there were three and five different VP4 MAb reactivity patterns, respectively, indicating that the diversity of neutralization epitopes in VP4 is greater than that previously appreciated by the genomic typing methods.

  • Copyright © 1998 American Society for Microbiology
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Antigenic and Genomic Diversity of Human Rotavirus VP4 in Two Consecutive Epidemic Seasons in Mexico
Luis Padilla-Noriega, Martha Méndez-Toss, Griselda Menchaca, Juan F. Contreras, Pedro Romero-Guido, Fernando I. Puerto, Héctor Guiscafré, Felipe Mota, Ismael Herrera, Roberto Cedillo, Onofre Muñoz, Juan Calva, María de Lourdes Guerrero, Barbara S. Coulson, Harry B. Greenberg, Susana López, Carlos F. Arias
Journal of Clinical Microbiology Jun 1998, 36 (6) 1688-1692; DOI: 10.1128/JCM.36.6.1688-1692.1998

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Antigenic and Genomic Diversity of Human Rotavirus VP4 in Two Consecutive Epidemic Seasons in Mexico
Luis Padilla-Noriega, Martha Méndez-Toss, Griselda Menchaca, Juan F. Contreras, Pedro Romero-Guido, Fernando I. Puerto, Héctor Guiscafré, Felipe Mota, Ismael Herrera, Roberto Cedillo, Onofre Muñoz, Juan Calva, María de Lourdes Guerrero, Barbara S. Coulson, Harry B. Greenberg, Susana López, Carlos F. Arias
Journal of Clinical Microbiology Jun 1998, 36 (6) 1688-1692; DOI: 10.1128/JCM.36.6.1688-1692.1998
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KEYWORDS

Capsid
Capsid Proteins
Disease Outbreaks
rotavirus
Rotavirus Infections

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