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Journal of Clinical Microbiology
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Bacteriology

Infection of Laboratory Mice with the Human Granulocytic Ehrlichiosis Agent Does Not Induce Antibodies to Diagnostically Significant Borrelia burgdorferiAntigens

Joseph E. Bunnell, Louis A. Magnarelli, J. Stephen Dumler
Joseph E. Bunnell
Department of Molecular Microbiology and Immunology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205;
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Louis A. Magnarelli
Department of Entomology, Connecticut Agricultural Experiment Station, New Haven, Connecticut 06504;
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J. Stephen Dumler
Department of Molecular Microbiology and Immunology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland 21205;
Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University Schools of Medicine, Baltimore, Maryland 21287; and
Department of Pathology, the University of Maryland School of Medicine, Baltimore, Maryland 21201
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DOI: 10.1128/JCM.37.6.2077-2079.1999
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ABSTRACT

Laboratory diagnosis of Borrelia burgdorferi is routinely made by an enzyme-linked immunosorbent assay, with positive results confirmed by Western blot analysis. Concern has been raised that false-positive diagnoses may be made on the basis of serologic cross-reactivity with antibodies directed against other bacterial pathogens, in particular the agent of human granulocytic ehrlichiosis (HGE). The present study made use of a mouse model to ascertain the validity of these concerns. Two different strains of mice were inoculated with the HGE agent and assayed for production of polyclonal and monoclonal antibodies to antigens of both of these bacteria. Infection of mice with the HGE agent does not induce diagnostically significant B. burgdorferi serologic cross-reactions.

  • Copyright © 1999 American Society for Microbiology
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Infection of Laboratory Mice with the Human Granulocytic Ehrlichiosis Agent Does Not Induce Antibodies to Diagnostically Significant Borrelia burgdorferiAntigens
Joseph E. Bunnell, Louis A. Magnarelli, J. Stephen Dumler
Journal of Clinical Microbiology Jun 1999, 37 (6) 2077-2079; DOI: 10.1128/JCM.37.6.2077-2079.1999

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Infection of Laboratory Mice with the Human Granulocytic Ehrlichiosis Agent Does Not Induce Antibodies to Diagnostically Significant Borrelia burgdorferiAntigens
Joseph E. Bunnell, Louis A. Magnarelli, J. Stephen Dumler
Journal of Clinical Microbiology Jun 1999, 37 (6) 2077-2079; DOI: 10.1128/JCM.37.6.2077-2079.1999
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KEYWORDS

Antibodies, Bacterial
Ehrlichia
Ehrlichiosis
Lyme disease

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