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Mycobacteriology and Aerobic Actinomycetes

Differentiation among Members of the Mycobacterium tuberculosis Complex by Molecular and Biochemical Features: Evidence for Two Pyrazinamide-Susceptible Subtypes ofM. bovis

Stefan Niemann, Elvira Richter, Sabine Rüsch-Gerdes
Stefan Niemann
Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany
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Elvira Richter
Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany
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Sabine Rüsch-Gerdes
Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel, Germany
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DOI: 10.1128/JCM.38.1.152-157.2000
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    Fig. 1.

    Spoligotypes and spoligotype groups among the M. tuberculosis complex isolates analyzed.

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    Biochemical and genetical characteristics of M. tuberculosis H37Rv and the strains analyzeda

    Organism and groupPZA sensitivityNiacin accumulationNitrate reductionGrowth in presence of TCHChange of color of bromcresol mediumColony morphology (growth)Growth on Lebek mediumPresence of mtb40Presence of pncA mutation (C to G)Presence of oxyR mutation (G to A)
    M. tuberculosis H37Rv (n = 1)S++++EugonicAerophilic+−−
    M. bovis
     Group 1 (n = 35)R (100)b− (100)− (100)− (100)− (100)Dysgonic (100)Microaerophilic (100)− (100)c+ (100)d+ (100)d
     Group 2 (n = 15)S (100)− (100)− (100)− (94), + (6)e− (100)Dysognic (100)Microaerophilic (100)− (100)− (100)d+ (100)d
     Group 3 (n = 2)S (100)− (100)− (100)− (100)− (100)Dysognic (100)Microaerophilic (100)− (100)− (100)+ (100)
    M. africanum
     Group 4 (n = 20)S (100)+ (55), − (45)+ (65), − (35)− (85), + (15)e− (100)Dysognic (100)Microaerophilic (100)+ (70), − (30)− (100)d− (100)d
     Group 5 (n = 24)S (100)+ (30), − (70)+ (100)+ (100)− (100)Dysognic (100)Microaerophilic (100)+ (100)− (100)d− (100)d
    • ↵a Abbreviations and symbols: S, susceptible, R, resistant; +, positive test result; −, negative test result.

    • ↵b Values in parentheses are percentage of isolates.

    • ↵c Ten randomly chosen strains were tested.

    • ↵d Five randomly chosen strains were tested.

    • ↵e Strains were resistant to isoniazid and cross-resistant to TCH.

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Differentiation among Members of the Mycobacterium tuberculosis Complex by Molecular and Biochemical Features: Evidence for Two Pyrazinamide-Susceptible Subtypes ofM. bovis
Stefan Niemann, Elvira Richter, Sabine Rüsch-Gerdes
Journal of Clinical Microbiology Jan 2000, 38 (1) 152-157; DOI: 10.1128/JCM.38.1.152-157.2000

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Differentiation among Members of the Mycobacterium tuberculosis Complex by Molecular and Biochemical Features: Evidence for Two Pyrazinamide-Susceptible Subtypes ofM. bovis
Stefan Niemann, Elvira Richter, Sabine Rüsch-Gerdes
Journal of Clinical Microbiology Jan 2000, 38 (1) 152-157; DOI: 10.1128/JCM.38.1.152-157.2000
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KEYWORDS

Antitubercular Agents
mycobacterium
Mycobacterium bovis
Mycobacterium tuberculosis
pyrazinamide

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