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Mycobacteriology and Aerobic Actinomycetes

Serum Interleukin-6 (IL-6), IL-10, Tumor Necrosis Factor (TNF) Alpha, Soluble Type II TNF Receptor, and Transforming Growth Factor Beta Levels in Human Immunodeficiency Virus Type 1-Infected Individuals with Mycobacterium avium Complex Disease

Diane V. Havlir, Francesca J. Torriani, Rachel D. Schrier, Jimmy Y. Huang, Michael M. Lederman, Keith A. Chervenak, W. Henry Boom
Diane V. Havlir
Department of Medicine, University of California, San Diego, California 92103, and
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Francesca J. Torriani
Department of Medicine, University of California, San Diego, California 92103, and
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Rachel D. Schrier
Department of Medicine, University of California, San Diego, California 92103, and
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Jimmy Y. Huang
Department of Medicine, University of California, San Diego, California 92103, and
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Michael M. Lederman
Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106
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Keith A. Chervenak
Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106
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W. Henry Boom
Department of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106
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DOI: 10.1128/JCM.39.1.298-303.2001
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    Fig. 1.

    Changes in levels of IL-6, IL-10, TNF-α, sTNF-RII, and TGF-β in serum after intitiation of antibiotic treatment for disseminated MAC infection. Cytokine and cytokine receptor protein levels in serum were measured by ELISA as described in Materials and Methods. Results are expressed either as the mean cytokine level for each time point (weeks 0 to 16) (A) or as the mean change from the baseline level (B). The values (mean cytokine level and mean change from the baseline level) for IL-6, IL-10, and TNF-α are in picograms per milliliter, and those for TGF-β and sTNF-RII are in nanograms per milliliter. The P values listed are for the linearity of change in cytokine over time compared to the baseline level.

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  • Table 1.

    Comparison of IL-6, IL-10, TNF-α, sTNF-RII, and TGF-β levels in serum at baseline and at the time of MAC bacteremia in patients with disseminated MAC and in controls

    Cytokine or receptor and time of measurementaMean levelb (SD) for: Pc
    Patients (n = 15) Controls (n = 15)
    IL-6 (pg/ml)
     Baseline 0.8 (1.0) 1.6 (3.3)NS
     Event 4.5 (12.3) 1.7 (4.7)NS
    IL-10 (pg/ml)
     Baseline 8.3 (7.3)9.1 (8.1) NS
     Event 22.7 (14.9) 20.9 (14.7)NS
    sTNF-α (pg/ml)
     Baseline 16.8 (13.1)20.9 (15.7) NS
     Event 37.1 (22.8) 31.4 (12.4)NS
    TNF-RII (ng/ml)
     Baseline 7.7 (2.1)6.7 (3.2) NS
     Event 9.1 (2.3) 6.9 (2.5) NS
    TGF-β (ng/ml)
     Baseline 45.1 (11.0)41.5 (11.3) NS
     Event 37.8 (15.9) 39.4 (13.1)NS
    • ↵a Event refers to MAC bacteremia for patients and a similar length of follow-up for controls.

    • ↵b Units are as indicated in column 1.

    • ↵c NS, not significant.

  • Table 2.

    Levels of IL-6, IL-10, TNF-α, sTNF-RII, and TGF-β in serum at time of disseminated MAC infection for cohorts 1 and 2 and posttreatment for cohort 2

    Cytokine or receptor Mean levela (SD)b
    At time of disseminated MAC infectionPostreatment (cohort 2 [n = 10] ) at:
    Cohort 1 (n = 15) Cohort 2 (n = 10) Wk 4 Wk 8
    IL-6 (pg/ml) 4.5 (12.3)10.5 (3.1) [0.15] 6.6 (2.4) 6.9 (4.6)
    IL-10 (pg/ml) 22.7 (14.9) 62.3 (69.0) [0.4] 27.0 (20.5)53.1 (70.7)
    TNF-α (pg/ml) 37.1 (22.8)24.5 (18.1) [0.7] 19.7 (18.5) 16.5 (12.2)
    sTNF-RII (ng/ml) 9.1 (2.3) 8.1 (5.9) [0.16]8.1 (5.9) 8.7 (5.5)
    TGF-β (ng/ml) 37.8 (15.9)35.4 (14.4) [0.56] 34.2 (11.0) 24.9 (13.3)
    • ↵a Units are as indicated in column 1.

    • ↵b P values are in brackets.

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Serum Interleukin-6 (IL-6), IL-10, Tumor Necrosis Factor (TNF) Alpha, Soluble Type II TNF Receptor, and Transforming Growth Factor Beta Levels in Human Immunodeficiency Virus Type 1-Infected Individuals with Mycobacterium avium Complex Disease
Diane V. Havlir, Francesca J. Torriani, Rachel D. Schrier, Jimmy Y. Huang, Michael M. Lederman, Keith A. Chervenak, W. Henry Boom
Journal of Clinical Microbiology Jan 2001, 39 (1) 298-303; DOI: 10.1128/JCM.39.1.298-303.2001

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Serum Interleukin-6 (IL-6), IL-10, Tumor Necrosis Factor (TNF) Alpha, Soluble Type II TNF Receptor, and Transforming Growth Factor Beta Levels in Human Immunodeficiency Virus Type 1-Infected Individuals with Mycobacterium avium Complex Disease
Diane V. Havlir, Francesca J. Torriani, Rachel D. Schrier, Jimmy Y. Huang, Michael M. Lederman, Keith A. Chervenak, W. Henry Boom
Journal of Clinical Microbiology Jan 2001, 39 (1) 298-303; DOI: 10.1128/JCM.39.1.298-303.2001
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KEYWORDS

AIDS-Related Opportunistic Infections
Anti-Bacterial Agents
Antigens, CD
cytokines
Mycobacterium avium-intracellulare Infection
Receptors, Tumor Necrosis Factor

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