Serum Interleukin-6 (IL-6), IL-10, Tumor Necrosis Factor (TNF) Alpha, Soluble Type II TNF Receptor, and Transforming Growth Factor Beta Levels in Human Immunodeficiency Virus Type 1-Infected Individuals with Mycobacterium avium Complex Disease

Changes in levels of IL-6, IL-10, TNF-α, sTNF-RII, and TGF-β in serum after intitiation of antibiotic treatment for disseminated MAC infection. Cytokine and cytokine receptor protein levels in serum were measured by ELISA as described in Materials and Methods. Results are expressed either as the mean cytokine level for each time point (weeks 0 to 16) (A) or as the mean change from the baseline level (B). The values (mean cytokine level and mean change from the baseline level) for IL-6, IL-10, and TNF-α are in picograms per milliliter, and those for TGF-β and sTNF-RII are in nanograms per milliliter. The P values listed are for the linearity of change in cytokine over time compared to the baseline level.