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Journal of Clinical Microbiology
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Epidemiology

High Disease Burden of Diarrhea Due to Enterotoxigenic Escherichia coli among Rural Egyptian Infants and Young Children

Malla R. Rao, Remon Abu-Elyazeed, Stephen J. Savarino, Abdollah B. Naficy, Thomas F. Wierzba, Ibrahim Abdel-Messih, Hind Shaheen, Robert W. Frenck Jr., Ann-Mari Svennerholm, John D. Clemens
Malla R. Rao
1Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda
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  • For correspondence: mr8u@nih.gov
Remon Abu-Elyazeed
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
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Stephen J. Savarino
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
3Naval Medical Research Center, Silver Spring, Maryland
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Abdollah B. Naficy
1Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda
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Thomas F. Wierzba
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
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Ibrahim Abdel-Messih
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
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Hind Shaheen
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
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Robert W. Frenck Jr.
2U.S. Naval Medical Research Unit No. 3, Cairo, Egypt
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Ann-Mari Svennerholm
4Department of Medical Microbiology and Immunology, University of Göteborg, Göteborg, Sweden
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John D. Clemens
1Epidemiology Branch, National Institute of Child Health and Human Development, Bethesda
5International Vaccine Institute, Seoul, South Korea
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DOI: 10.1128/JCM.41.10.4862-4864.2003
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    FIG. 1.

    Time to first infection resulting in diarrhea due to any pathogen isolated (ALL CAUSE), any ETEC, ST-ETEC, or LT-ETEC in a cohort of 211 new-birth infants in Abu Homos, Egypt, from 1995 to 1998.

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    FIG. 2.

    Monthly incidence (episodes per child per year) of ETEC diarrhea in Abu Homos, Egypt, from 1995 to 1998 (with a smoothing fit to illustrate monthly variability).

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  • TABLE 1.

    Annual age-specific incidence rates (episodes per child per year) of all-cause diarrhea, ETEC diarrhea, and diarrhea due to other enteropathogens in Abu Homos, Egypt, from 1995 to 1998

    AgeaIncidence rate in episodes/child/yr of diarrhea (no. of cases) caused by:
    All causesAll ETEC typesLT-ETECbST-ETECbLTST-ETECbCampylobacterShigellaRotavirusAstrovirus
    0-57.33 (681)1.67 (155)0.53 (49)0.91 (85)0.18 (17)0.87 (81)0.08 (7)0.19 (18)0.38 (35)
    6-118.81 (913)2.26 (234)0.62 (64)1.24 (129)0.31 (32)1.48 (153)0.24 (25)0.38 (39)0.40 (41)
    12-176.40 (731)1.99 (227)0.51 (58)1.11 (127)0.28 (32)0.58 (66)0.42 (48)0.26 (30)0.18 (21)
    18-234.61 (542)1.35 (159)0.26 (31)0.87 (102)0.20 (24)0.29 (34)0.24 (28)0.13 (15)0.14 (16)
    24-352.92 (610)0.76 (158)0.17 (35)0.48 (101)0.11 (22)0.15 (32)0.12 (26)0.08 (16)0.05 (10)
    All ages5.46 (3,477)1.47 (933)0.37 (237)0.85 (544)0.20 (127)0.57 (366)0.21 (134)0.19 (118)0.19 (123)
    • ↵ a Child age in months at the time of follow-up.

    • ↵ b Results do not include findings for ETECs in which different colonies from the same fecal specimen express different toxins.

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High Disease Burden of Diarrhea Due to Enterotoxigenic Escherichia coli among Rural Egyptian Infants and Young Children
Malla R. Rao, Remon Abu-Elyazeed, Stephen J. Savarino, Abdollah B. Naficy, Thomas F. Wierzba, Ibrahim Abdel-Messih, Hind Shaheen, Robert W. Frenck Jr., Ann-Mari Svennerholm, John D. Clemens
Journal of Clinical Microbiology Oct 2003, 41 (10) 4862-4864; DOI: 10.1128/JCM.41.10.4862-4864.2003

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High Disease Burden of Diarrhea Due to Enterotoxigenic Escherichia coli among Rural Egyptian Infants and Young Children
Malla R. Rao, Remon Abu-Elyazeed, Stephen J. Savarino, Abdollah B. Naficy, Thomas F. Wierzba, Ibrahim Abdel-Messih, Hind Shaheen, Robert W. Frenck Jr., Ann-Mari Svennerholm, John D. Clemens
Journal of Clinical Microbiology Oct 2003, 41 (10) 4862-4864; DOI: 10.1128/JCM.41.10.4862-4864.2003
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KEYWORDS

Bacterial Toxins
diarrhea
Enterotoxins
Escherichia coli
Escherichia coli Proteins
Rural Population

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