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Bacteriology

C6 Test as an Indicator of Therapy Outcome for Patients with Localized or Disseminated Lyme Borreliosis

Mario T. Philipp, Adriana R. Marques, Paul T. Fawcett, Leonard G. Dally, Dale S. Martin
Mario T. Philipp
1Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana
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  • For correspondence: Philipp@tpc.tulane.edu
Adriana R. Marques
2Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda
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Paul T. Fawcett
3Alfred I. duPont Hospital for Children, Wilmington, Delaware
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Leonard G. Dally
4The EMMES Corporation, Rockville, Maryland
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Dale S. Martin
1Division of Bacteriology and Parasitology, Tulane National Primate Research Center, Tulane University Health Sciences Center, Covington, Louisiana
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DOI: 10.1128/JCM.41.11.4955-4960.2003
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    FIG. 1.

    Decrease in rGMT, expressed as rGMT1/rGMT2, as a function of the interval (in months) between the first and second serum sample collections.

Tables

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  • TABLE 1.

    Comparative sensitivities of the whole-cell Lyme ELISA, Western blotting, two-tiered algorithm, and C6 test

    Disease stageNo. of patientsNo. (%) of patients positive by:
    ELISAWestern blottingTwo-tiered algorithmC6 test
    EM399 (23)11 (28)4 (10)17 (44)
    Disseminated9280 (87)90 (98)78 (85)81 (88)
        Total13189 (68)101 (77)82 (63)98 (75)
  • TABLE 2.

    Distribution of patients who did or did not experience a ≥4-fold decline in anti-C6 antibody GMT at ≥6 months after diagnosis

    Disease stageC6 GMT ≥4-fold lower than at baseline (no. of patients)Total
    YesNo
    EM11011
    Disseminated25934
        Total36945
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C6 Test as an Indicator of Therapy Outcome for Patients with Localized or Disseminated Lyme Borreliosis
Mario T. Philipp, Adriana R. Marques, Paul T. Fawcett, Leonard G. Dally, Dale S. Martin
Journal of Clinical Microbiology Nov 2003, 41 (11) 4955-4960; DOI: 10.1128/JCM.41.11.4955-4960.2003

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C6 Test as an Indicator of Therapy Outcome for Patients with Localized or Disseminated Lyme Borreliosis
Mario T. Philipp, Adriana R. Marques, Paul T. Fawcett, Leonard G. Dally, Dale S. Martin
Journal of Clinical Microbiology Nov 2003, 41 (11) 4955-4960; DOI: 10.1128/JCM.41.11.4955-4960.2003
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KEYWORDS

Lyme disease

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