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Journal of Clinical Microbiology
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Bacteriology

Evolution of a Vancomycin-Intermediate Staphylococcus aureus Strain In Vivo: Multiple Changes in the Antibiotic Resistance Phenotypes of a Single Lineage of Methicillin-Resistant S. aureus under the Impact of Antibiotics Administered for Chemotherapy

K. Sieradzki, T. Leski, J. Dick, L. Borio, A. Tomasz
K. Sieradzki
1The Rockefeller University, New York, New York 10021
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T. Leski
1The Rockefeller University, New York, New York 10021
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J. Dick
2John Hopkins Medical Institutions, Baltimore, Maryland 21287
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L. Borio
2John Hopkins Medical Institutions, Baltimore, Maryland 21287
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A. Tomasz
1The Rockefeller University, New York, New York 10021
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  • For correspondence: tomasz@mail.rockefeller.edu
DOI: 10.1128/JCM.41.4.1687-1693.2003
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Article Information

DOI 
https://doi.org/10.1128/JCM.41.4.1687-1693.2003
PubMed 
12682161

Published By 
American Society for Microbiology Journals
History 
  • Received October 2, 2002
  • Returned for modification November 29, 2002
  • Accepted January 7, 2003
  • Published online April 1, 2003.

Copyright & Usage 
Copyright © 2003 American Society for Microbiology

Author Information

  1. K. Sieradzki1,
  2. T. Leski1,
  3. J. Dick2,
  4. L. Borio2 and
  5. A. Tomasz1*
  1. 1The Rockefeller University, New York, New York 10021
  2. 2John Hopkins Medical Institutions, Baltimore, Maryland 21287
  • ↵* Corresponding author. Mailing address: The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327-8277. Fax: (212) 327-8688. E-mail: tomasz{at}mail.rockefeller.edu .
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Evolution of a Vancomycin-Intermediate Staphylococcus aureus Strain In Vivo: Multiple Changes in the Antibiotic Resistance Phenotypes of a Single Lineage of Methicillin-Resistant S. aureus under the Impact of Antibiotics Administered for Chemotherapy
K. Sieradzki, T. Leski, J. Dick, L. Borio, A. Tomasz
Journal of Clinical Microbiology Apr 2003, 41 (4) 1687-1693; DOI: 10.1128/JCM.41.4.1687-1693.2003

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Evolution of a Vancomycin-Intermediate Staphylococcus aureus Strain In Vivo: Multiple Changes in the Antibiotic Resistance Phenotypes of a Single Lineage of Methicillin-Resistant S. aureus under the Impact of Antibiotics Administered for Chemotherapy
K. Sieradzki, T. Leski, J. Dick, L. Borio, A. Tomasz
Journal of Clinical Microbiology Apr 2003, 41 (4) 1687-1693; DOI: 10.1128/JCM.41.4.1687-1693.2003
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  • Top
  • Article
    • ABSTRACT
    • MATERIALS AND METHODS
    • Antibiotic susceptibility.
    • Time-kill curves.
    • DNA manipulations.
    • MLST and spaA typing.
    • Detection of mecA.
    • RESULTS AND DISCUSSION
    • Changes in oxacillin and vancomycin susceptibilities as a function of the chronological date of isolation of JH strains.
    • Changes in growth rate and susceptibility to the bactericidal effect of vancomycin as a function of the chronological dates of isolation of JH strains.
    • Vancomycin susceptibility of MRSA strain PA237.
    • ADDENDUM
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
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KEYWORDS

bacteremia
Drug Resistance, Bacterial
Staphylococcal Infections
Staphylococcus aureus
vancomycin

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