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Mycobacteriology and Aerobic Actinomycetes

Molecular Characteristics and Global Spread of Mycobacterium tuberculosis with a Western Cape F11 Genotype

Thomas C. Victor, Petra E. W. de Haas, Annemarie M. Jordaan, Gian D. van der Spuy, Madalene Richardson, D. van Soolingen, Paul D. van Helden, Robin Warren
Thomas C. Victor
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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  • For correspondence: tv@sun.ac.za
Petra E. W. de Haas
2Diagnostic Laboratory for Infectious Disease and Perinatal Screening, Mycobacteria Department, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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Annemarie M. Jordaan
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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Gian D. van der Spuy
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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Madalene Richardson
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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D. van Soolingen
2Diagnostic Laboratory for Infectious Disease and Perinatal Screening, Mycobacteria Department, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
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Paul D. van Helden
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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Robin Warren
1MRC Centre for Molecular and Cellular Biology, Department of Medical Biochemistry, University of Stellenbosch, Tygerberg 7505, South Africa
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DOI: 10.1128/JCM.42.2.769-772.2004
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    FIG. 1.

    Worldwide distribution of the Western Cape F11 genotype family. Results are from the international RFLP database in The Netherlands (see countries in Table 1) and the spoligotype database in Gaudeloupe (The Netherlands, Chile, Honduras, Cuba, France, Italy, Austria, United Kingdom, Spain, Brazil, Argentina, French Guiana, Sweden, Venezuela, and United States).

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  • TABLE 1.

    Countries in which the Western Cape genotype F11 was found in the RFLP international database

    Continent (countries)aNo. of IS6110 DNA fingerprints available for comparisonNo. (%) of isolates matching with F11
    Asia (China [300], India [154], Indonesia [93], Iran [98], Israel [14], Malaysia [2], Mongolia [23], Philippines [46], South Korea [14], Thailand [64], United Arab Emirates [8], Vietnam [424]),1,2320 (0.0)
    Europe (Austria [161, 1], Czech Republic [198, 1], Germany [348, 2], Denmark [729, 13], Italy [760, 17], The Netherlandsb [9998, 245], Russia [5], Spain [78, 10], Switzerland [17], United Kingdom [110, 2])12,404291 (2.3)
    North Africa (Tunisia [228, 8], Ethiopia [184], Morocco [8])4208 (1.9)
    Central Africa (Tanzania [131, 1], Burundi [1], Comoros [3], Guinea [5], Rwanda [58])1981 (0.5)
    Southern Africa (Zambia [188, 8], South Africac [1,203, 229])1,391237 (17.0)
    North America (United States [8, 1], Canada [40, 2], Honduras [11, 2], Cuba [185, 14])24419 (7.8)
    South America (Chile [3, 2], Argentina [45, 3], Venuzuela [19, 3], Brazil [80, 4], Bolivia [55, 5], Colombia [1], Equador [3], Peru [1])20717 (8.2)
    Total16,096573
    • ↵ a The number of IS6110 RFLP patterns available in the international database and the number of isolates with an F11 RFLP pattern found is indicated in brackets.

    • ↵ b Patterns in the Dutch database.

    • ↵ c Patterns in the South Africa and international database.

  • TABLE 2.

    Key molecular characteristics that define F11 isolates

    CharacteristicReference
    Principal genetic group 2 (katG463 CGG; gyrA95 ACC)20
    Polymorphism at rrs491 (C-T)16; this study
    IS6110 banding pattern, from 11 to 19 inserts (average, 14)16; this study
    Spoligotype 33 (spacers 9 to 11, 21 to 24, and 33 to 36 deleted)21; this study
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Molecular Characteristics and Global Spread of Mycobacterium tuberculosis with a Western Cape F11 Genotype
Thomas C. Victor, Petra E. W. de Haas, Annemarie M. Jordaan, Gian D. van der Spuy, Madalene Richardson, D. van Soolingen, Paul D. van Helden, Robin Warren
Journal of Clinical Microbiology Feb 2004, 42 (2) 769-772; DOI: 10.1128/JCM.42.2.769-772.2004

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Molecular Characteristics and Global Spread of Mycobacterium tuberculosis with a Western Cape F11 Genotype
Thomas C. Victor, Petra E. W. de Haas, Annemarie M. Jordaan, Gian D. van der Spuy, Madalene Richardson, D. van Soolingen, Paul D. van Helden, Robin Warren
Journal of Clinical Microbiology Feb 2004, 42 (2) 769-772; DOI: 10.1128/JCM.42.2.769-772.2004
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KEYWORDS

Mycobacterium tuberculosis
tuberculosis

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