Population-Based Case Control Study of Seroprevalence of Mycobacterium paratuberculosis in Patients with Crohn's Disease and Ulcerative Colitis

DOI: 10.1128/JCM.42.3.1129-1135.2004

Article Figures & Data

TABLE 1.

Demographic characteristics of the study groups

Parameter	Value for group^a
Parameter	Crohn's disease	Ulcerative colitis	Healthy controls	Sibling controls
Age (yr)
Mean	36.4 ± 7.8^	37.4 ± 7.6^	39.8 ± 5.6	39.3 ± 8.5
range	18-50	18-50	24-49	20-50
Gender (% female)	60.8^	54.9^	72.4	60.1
Urban living (%)	58.4	63.2	59.1	48.5
Born in developing nation (%)	1.1	3.0	2.9	0.6
Childhood consumption of^b:
Milk (mean ± SD)	4.65 ± 0.89	4.51 ± 1.09	4.7 ± 0.83	4.63 ± 0.92
Unpasteurized milk	1.07 ± 1.81^	1.23 ± 1.93^^	1.72 ± 2.18	1.57 ± 2.08
Chicken	2.94 ± 0.66^^	3.01 ± 0.65^^	2.82 ± 0.65	2.88 ± 0.64
Beef	3.34 ± 0.73	3.35 ± 0.68	3.37 ± 0.74	3.32 ± 0.72
Pork	2.44 ± 0.87	2.49 ± 0.86	2.55 ± 0.77	2.59 ± 0.79
Childhood primary water source other than tap (%)^c	29^^	30.9^^	37.4	42.7
Ever lived on a poultry farm	10.6	13.8^^	8.2	14.5
Ever lived on dairy or beef farm	13.1	18.7^^	14.8	23.7
Ever lived on pig farm	7.5	12.3^^	6.7	16.3

↵ a n values were as follows: for Crohn's disease group, 283; for ulcerative colitis group, 144; for healthy controls, 402; and for sibling controls, 138. ^,P < 0.001 versus control; ^^, P ≤ 0.03 versus control.
↵ b Values are means ± standard deviations and indicate frequency of consumption based on the following scale: 0, never; 1, less than once a month; 2, 1 to 3 times a month; 3, 1 to 2 times a week; 4, 3 to 6 times a week; 5, every day. The statistics highlighted in the table are for comparisons of means of scores.
↵ c Subjects were given a choice of primary water source during childhood of tap water, well water, or other water sources.

TABLE 2.

Percentage of M. paratuberculosis-seropositive subjects by demographic variables

Variable	% M. paratuberculosis seropositive	Odds ratio (95% CI)
First-degree family member with IBD
Positive	34.8	1.01 (0.74-1.37)
Negative	34.9	1.00
Birth in non-Western nation
Positive	33.3	0.93 (0.35-2.50)
Negative	35.0	1.00
Gender
Female	35.9	1.11 (0.84-1.47)
Male	33.5	1.00
Urban residence
Positive	37.3	1.27 (0.96-1.68)
Negative	31.9	1.00
Primary non-tap water source as child
Positive	33.9	0.93 (0.69-1.26)
Negative	35.6	1.00
Lived on poultry farm
Positive	27.6	0.68 (0.43-1.06)
Negative	36.1	1.00
Lived on dairy/beef farm
Positive	33.5	0.92 (0.65-1.31)
Negative	35.4	1.00
Lived on pig farm
Positive	34.4	0.97 (0.62-1.51)
Negative	35.2	1.00