Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison; Salman H. Siddiqi; Leonid Heifets; Wendy Gross; Mike Higgins; Nancy Warren; Anthony Thompson; Glenn Morlock; John C. Ridderhof

doi:10.1128/JCM.42.3.1294-1295.2004

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Mycobacteriology and Aerobic Actinomycetes

Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof

Bereneice M. Madison

1Division of Laboratory Systems, Public Health Practice Program Office

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For correspondence: bdm6@cdc.gov

Salman H. Siddiqi

2Becton Dickinson Microbiology Systems, Sparks, Maryland 21152

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Leonid Heifets

3National Jewish Medical and Research Center, Denver, Colorado 80206

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Wendy Gross

4VA TB Reference Laboratory, West Haven, Connecticut 06516

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Mike Higgins

3National Jewish Medical and Research Center, Denver, Colorado 80206

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Nancy Warren

5Laboratory Corporation of America, Burlington, North Carolina 27215

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Anthony Thompson

5Laboratory Corporation of America, Burlington, North Carolina 27215

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Glenn Morlock

6National Center for HIV, STD and TB Prevention, Centers for Disease ControlPrevention, Atlanta, Georgia

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John C. Ridderhof

1Division of Laboratory Systems, Public Health Practice Program Office

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DOI: 10.1128/JCM.42.3.1294-1295.2004

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TABLE 1.
DNA sequence results for M. tuberculosis low-level INH-resistant strains^a
Strain inhA promoter inhA ORF katG codon 315 region
A C (−15) → T WT WT
B WT WT Ser 302 → Arg (AGC → CGC)
C WT WT WT
D WT WT WT
↵ a Abbreviations: ORF, open reading frame; WT, wild type.

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Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof

Journal of Clinical Microbiology Mar 2004, 42 (3) 1294-1295; DOI: 10.1128/JCM.42.3.1294-1295.2004

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Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof

Journal of Clinical Microbiology Mar 2004, 42 (3) 1294-1295; DOI: 10.1128/JCM.42.3.1294-1295.2004

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KEYWORDS

Antimalarials

Drug Resistance, Bacterial

isoniazid

Mycobacterium tuberculosis

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Strain	inhA promoter	inhA ORF	katG codon 315 region
A	C (−15) → T	WT	WT
B	WT	WT	Ser 302 → Arg (AGC → CGC)
C	WT	WT	WT
D	WT	WT	WT

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