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Mycobacteriology and Aerobic Actinomycetes

Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid

Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof
Bereneice M. Madison
1Division of Laboratory Systems, Public Health Practice Program Office
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  • For correspondence: bdm6@cdc.gov
Salman H. Siddiqi
2Becton Dickinson Microbiology Systems, Sparks, Maryland 21152
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Leonid Heifets
3National Jewish Medical and Research Center, Denver, Colorado 80206
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Wendy Gross
4VA TB Reference Laboratory, West Haven, Connecticut 06516
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Mike Higgins
3National Jewish Medical and Research Center, Denver, Colorado 80206
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Nancy Warren
5Laboratory Corporation of America, Burlington, North Carolina 27215
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Anthony Thompson
5Laboratory Corporation of America, Burlington, North Carolina 27215
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Glenn Morlock
6National Center for HIV, STD and TB Prevention, Centers for Disease ControlPrevention, Atlanta, Georgia
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John C. Ridderhof
1Division of Laboratory Systems, Public Health Practice Program Office
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DOI: 10.1128/JCM.42.3.1294-1295.2004
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Tables

  • TABLE 1.

    DNA sequence results for M. tuberculosis low-level INH-resistant strainsa

    StraininhA promoterinhA ORFkatG codon 315 region
    AC (−15) → TWTWT
    BWTWTSer 302 → Arg (AGC → CGC)
    CWTWTWT
    DWTWTWT
    • ↵ a Abbreviations: ORF, open reading frame; WT, wild type.

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Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid
Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof
Journal of Clinical Microbiology Mar 2004, 42 (3) 1294-1295; DOI: 10.1128/JCM.42.3.1294-1295.2004

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Identification of a Mycobacterium tuberculosis Strain with Stable, Low-Level Resistance to Isoniazid
Bereneice M. Madison, Salman H. Siddiqi, Leonid Heifets, Wendy Gross, Mike Higgins, Nancy Warren, Anthony Thompson, Glenn Morlock, John C. Ridderhof
Journal of Clinical Microbiology Mar 2004, 42 (3) 1294-1295; DOI: 10.1128/JCM.42.3.1294-1295.2004
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KEYWORDS

Antimalarials
Drug Resistance, Bacterial
isoniazid
Mycobacterium tuberculosis

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