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Virology

Use of an Immunoglobulin G Avidity Test To Discriminate between Primary and Secondary Dengue Virus Infections

Vanda Akico Ueda Fick de Souza, Silvana Fernandes, Evaldo Stanislau Araújo, Adriana Fumie Tateno, Olímpia M. N. P. F. Oliveira, Renato dos Reis Oliveira, Cláudio Sérgio Pannuti
Vanda Akico Ueda Fick de Souza
1Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo
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Silvana Fernandes
1Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo
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Evaldo Stanislau Araújo
2Hospital Ana Costa, Santos, São Paulo, Brazil
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Adriana Fumie Tateno
1Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo
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Olímpia M. N. P. F. Oliveira
2Hospital Ana Costa, Santos, São Paulo, Brazil
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Renato dos Reis Oliveira
1Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo
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Cláudio Sérgio Pannuti
1Laboratório de Virologia (LIMHC-52), Instituto de Medicina Tropical de São Paulo, Departamento de Moléstias Infecciosas e Parasitárias da Faculdade de Medicina, Universidade de São Paulo
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DOI: 10.1128/JCM.42.4.1782-1784.2004
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    FIG. 1.

    IgG antibody avidity in sera from patients with primary and secondary dengue infections with washing schedules of 7 M urea for 10 min and 8 M urea for 5 min.

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  • TABLE 1.

    Performance of IgG avidity test with convalescent-phase sera from patients with primary and secondary dengue infectionsa

    AI rangeData for patients with:
    Primary infectionSecondary infection
    No. (%) of patientsMean AI (SD)No. (%) of patientsMean AI (SD)
    ≥240 (0.0)28 (93.3)52 (16.7)
    <2427 (100.0)12 (4.6)2 (6.7)21 (2.8)
    Total27 (100.0)12 (4.6)30 (100.0)50 (18)
    • ↵ a AI, avidity index.

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Use of an Immunoglobulin G Avidity Test To Discriminate between Primary and Secondary Dengue Virus Infections
Vanda Akico Ueda Fick de Souza, Silvana Fernandes, Evaldo Stanislau Araújo, Adriana Fumie Tateno, Olímpia M. N. P. F. Oliveira, Renato dos Reis Oliveira, Cláudio Sérgio Pannuti
Journal of Clinical Microbiology Apr 2004, 42 (4) 1782-1784; DOI: 10.1128/JCM.42.4.1782-1784.2004

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Use of an Immunoglobulin G Avidity Test To Discriminate between Primary and Secondary Dengue Virus Infections
Vanda Akico Ueda Fick de Souza, Silvana Fernandes, Evaldo Stanislau Araújo, Adriana Fumie Tateno, Olímpia M. N. P. F. Oliveira, Renato dos Reis Oliveira, Cláudio Sérgio Pannuti
Journal of Clinical Microbiology Apr 2004, 42 (4) 1782-1784; DOI: 10.1128/JCM.42.4.1782-1784.2004
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KEYWORDS

Antibodies, Viral
Antibody Affinity
dengue
dengue virus
immunoglobulin G

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