Article Figures & Data
Figures
- FIG. 1.
ROC curves for 3ABC CHEKIT ELISA (AUC = 0.782) and C-ELISA (AUC = 0.865) for adult and juvenile animals (n = 1,377). Two-tailed test of AUC Z statistic = 5.217; P < 0.01. Arrows mark the recommended cutoffs for each test.
- FIG. 2.
ROC curves for CHEKIT ELISA (AUC = 0.707) and C-ELISA (AUC = 0.829) based on juveniles only (n = 651). Two-tailed test of AUC Z statistic = 4.64; P < 0.01.
- FIG. 3.
Scatter plots of the OD readings for the CHEKIT ELISA (+, >30%) and C-ELISA (+, ≤50%) plotted against the number of months since the herdsman reported the last outbreak of FMD for animals that were probang culture positive (n = 38). Cutoffs are marked with horizontal lines.
Tables
- TABLE 1.
Estimates of Se and Sp for the CHEKIT ELISA and the C-ELISA compared to the cVNT as a gold standarda
cVNT result CHEKIT result No. of animals with C-ELISA result that was: + − Seropositiveb + 205 7 − 443 252 Seronegativec + 6 4 − 41 419 ↵ a Total number of animals tested, 1,377. The recommended cutoffs of 30% for the CHEKIT ELISA and 50% for the C-ELISA were used.
↵ b Se of CHEKIT ELISA = 0.234; Se of C-ELISA = 0.714; kappa value of 0.192 between CHEKIT and C-ELISA results.
↵ c Sp of CHEKIT ELISA = 0.979; Sp of C-ELISA = 0.900; kappa value of 0.182 between CHEKIT and C-ELISA results.
- TABLE 2.
Estimates of Se and Sp for the CHEKIT ELISA and the C-ELISA based on subset of juvenile animals and compared to the cVNT as the gold standarda
cVNT result CHEKIT result No. of animals with C-ELISA result that was: + − Seropositiveb + 46 2 − 136 134 Seronegativec + 2 4 − 17 310 ↵ a Total number of animals tested, 651. The recommended cutoffs of 30% for the CHEKIT ELISA and 50% for the C-ELISA were used.
↵ b Se of CHEKIT ELISA = 0.151; Se of C-ELISA = 0.572; kappa value of 0.212 between CHEKIT and C-ELISA results.
↵ c Sp of CHEKIT ELISA = 0.982; Sp of C-ELISA = 0.942; kappa value of 0.136 between CHEKIT and C-ELISA results.
- TABLE 3.
HSe and HSp of the CHEKIT ELISAa
No. of animals tested HSp (0, 2)b HSe for herd with indicated characteristics 1, 2b 5, 3 10, 4 20, 6 30, 8 5 0.902 0.098 0.144 0.188 0.271 0.347 15 0.721 0.279 0.389 0.484 0.633 0.741 25 0.561 0.439 0.582 0.690 0.831 0.909 35 0.420 0.580 0.730 0.827 0.931 0.973 45 0.300 0.700 0.838 0.913 0.976 0.993 55 0.200 0.800 0.912 0.962 0.993 0.999 - TABLE 4.
HSe and HSp of the C-ELISAa
No. of animals tested HSp (0, 10)b HSe for herd with indicated characteristics 1, 11b 5, 13 10, 16 20, 22 30, 28 5 0.584 0.449 0.509 0.590 0.720 0.814 15 0.181 0.849 0.896 0.942 0.983 0.995 25 0.048 0.965 0.982 0.994 0.999 1.000 35 0.010 0.994 0.998 1.000 1.000 1.000 45 0.002 0.999 1.000 1.000 1.000 1.000 55 0.000 1.000 1.000 1.000 1.000 1.000
