Mycobacterium avium subsp. paratuberculosis, Genetic Susceptibility to Crohn's Disease, and Sardinians: the Way Ahead

Leonardo A. Sechi; Maria Gazouli; John Ikonomopoulos; John C. Lukas; Antonio M. Scanu; Niyaz Ahmed; Giovanni Fadda; Stefania Zanetti

doi:10.1128/JCM.43.10.5275-5277.2005

DOI: 10.1128/JCM.43.10.5275-5277.2005

Article Figures & Data

Tables

TABLE 1.

Patient details^a

Patient	Sex	Disease or group	PCR result (presence of M. avium subsp. paratuberculosis)	Genetic analysis result for indicated allele			Patient	Sex	Disease or group	Genetic analysis result for indicated allele
Patient	Sex	Disease or group		insC3020	R702W	G908R	Patient	Sex	Disease or group	insC3020	R702W	G908R
4	F	Crohn's disease	Pos	WT	WT	WT
6	F	Crohn's disease	Pos	HET	WT	WT
9	M	Crohn's disease	Pos	WT	WT	WT
10	M	Crohn's disease	Pos	WT	HET	WT
15	M	Crohn's disease	Pos	HET	WT	HET
16	M	Crohn's disease	Pos	WT	WT	WT
19	F	Crohn's disease	Pos	WT	HET	WT
24	F	Crohn's disease	Pos	WT	WT	WT
25	F	Crohn's disease	Pos	HOM	WT	HOM
28	F	Crohn's disease	Pos	WT	WT	WT
29	M	Crohn's disease	Neg	WT	WT	WT
55	F	Crohn's disease	Pos	WT	HET	HET
62	M	Crohn's disease	Neg	HET	WT	WT
63	M	Crohn's disease	Pos	WT	WT	WT
66	F	Crohn's disease	Pos	WT	WT	WT
67	M	Crohn's disease	Pos	WT	WT	HET
69	F	Crohn's disease	Neg	WT	WT	WT
72	M	Crohn's disease	Neg	WT	WT	WT
74	M	Crohn's disease	Pos	HET	HET	WT
78	F	Crohn's disease	Pos	WT	WT	WT
79	F	Crohn's disease	Neg	WT	WT	HET
81	M	Crohn's disease	Neg	WT	WT	WT
82	F	Crohn's disease	Pos	HET	WT	WT
83	M	Crohn's disease	Pos	WT	WT	WT
91	F	Crohn's disease	Neg	WT	WT	WT
107	M	Crohn's disease	Neg	WT	WT	WT
110	F	Crohn's disease	Neg	WT	WT	HET
111	F	Crohn's disease	Pos	WT	WT	WT
113	F	Crohn's disease	Pos	HET	WT	WT
117	F	Crohn's disease	Pos	WT	WT	WT
120	F	Crohn's disease	Neg	HET	WT	WT
125	M	Crohn's disease	Neg	WT	HET	WT
127	F	Crohn's disease	Neg	WT	WT	WT
130	F	Crohn's disease	Pos	HET	HET	WT
132	F	Crohn's disease	Pos	WT	HET	WT
133	F	Crohn's disease	Pos	HET	WT	WT
135	R	Crohn's disease	Pos	WT	HET	WT
5	M	Control	Pos	WT	HET	WT
26	F	Control	Neg	WT	WT	WT
54	M	Control	Pos	WT	WT	WT
56	M	Control	Pos	WT	WT	WT
57	M	Control	Neg	WT	WT	WT
58	M	Control	Neg	HET	WT	WT
59	M	Control	Neg	WT	WT	WT
60	F	Control	Neg	WT	WT	WT
64	F	Control	Neg	WT	WT	WT
65	F	Control	Neg	WT	WT	WT
68	F	Control	Neg	WT	WT	WT
70	M	Control	Neg	WT	WT	WT
71	M	Control	Neg	WT	WT	WT
73	M	Control	Neg	WT	WT	HET
75	M	Control	Neg	WT	WT	WT
77	F	Control	Neg	WT	WT	WT
84	M	Control	Neg	WT	WT	WT
85	F	Control	Neg	WT	WT	WT
87	F	Control	Neg	WT	WT	WT
88	F	Control	Neg	HET	WT	WT
89	F	Control	Neg	WT	WT	HET
93	F	Control	Neg	WT	WT	WT
103	F	Control	Neg	WT	WT	WT
105	M	Control	Neg	WT	WT	WT
108	M	Control	Neg	WT	WT	WT
114	F	Control	Pos	WT	WT	WT
116	M	Control	Pos	WT	WT	WT
118	M	Control	Pos	WT	WT	WT
128	F	Control	Neg	WT	WT	WT
131	F	Control	Pos	HET	WT	WT
137	M	Control	Neg	WT	WT	WT
138	F	Control	Neg	WT	HET	WT
139	F	Control	Neg	WT	WT	WT
140	F	Control	Neg	WT	WT	WT

↵ a Abbreviations: M, male; F, female. Results of genetic analysis of the alleles of the NOD2/CARD15 gene are reported as wild type (WT), heterozygous for the mutation (HET), and homozygous for the mutation (HOM). Results of PCR for M. avium subsp. paratuberculosis DNA are shown as positive (Pos) or negative (Neg).