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Bacteriology

Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus

M. K. Hayden, K. Rezai, R. A. Hayes, K. Lolans, J. P. Quinn, R. A. Weinstein
M. K. Hayden
1Rush University Medical Center, Chicago, Illinois
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  • For correspondence: mhayden@rush.edu
K. Rezai
1Rush University Medical Center, Chicago, Illinois
2Stroger (Cook County) Hospital, Chicago, Illinois
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R. A. Hayes
1Rush University Medical Center, Chicago, Illinois
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K. Lolans
2Stroger (Cook County) Hospital, Chicago, Illinois
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J. P. Quinn
1Rush University Medical Center, Chicago, Illinois
2Stroger (Cook County) Hospital, Chicago, Illinois
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R. A. Weinstein
1Rush University Medical Center, Chicago, Illinois
2Stroger (Cook County) Hospital, Chicago, Illinois
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DOI: 10.1128/JCM.43.10.5285-5287.2005
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    FIG. 1.

    Time-kill experiments with representative daptomycin-susceptible and daptomycin-resistant methicillin-resistant Staphylococcus aureus isolates. (A) Daptomycin-susceptible isolate from patient 1. (B) Daptomycin-resistant isolate from patient 1. (C) Daptomycin-susceptible isolate from patient 2. (D) Daptomycin-resistant isolate from patient 2. Abbreviations: C, Growth control without daptomycin; 1× MIC, 2× MIC, and 4× MIC, daptomycin concentrations tested were equal to, twice, and four times higher than the MIC of daptomycin for the isolate, respectively.

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  • TABLE 1.

    Daptomycin susceptibility testing of clinical methicillin-resistant Staphylococcus aureus isolates

    Isolate sourceSample typeDate of isolation (mo/day/yr)Disk zone size (mm)aMIC (μg/ml)b
    Patient 1cTibial tissue12/31/03220.25
    Synovial fluid12/31/03220.25
    Blood1/2/04220.25
    Blood1/2/04220.25
    Blood1/7/04220.25
    Blood1/7/04220.25
    Blood1/8/04220.25
    Blood1/8/04220.25
    Blood1/9/04220.25
    Blood1/9/04220.25
    Blood2/12/04184
    Epidural tissue2/18/04184
    Patient 2dBlood12/9/03230.5
    Blood3/3/04230.5
    Blood3/5/04240.5
    Blood3/7/04240.5
    Blood3/11/04232
    Blood5/2/04192
    Blood5/2/04202
    Blood5/3/04202
    Blood5/4/04192
    Blood5/6/04194
    Blood5/7/04202
    Blood5/9/04202
    Blood5/11/04194
    Blood5/11/04192
    Blood5/13/04194
    • ↵ a Tested by the disk diffusion method.

    • ↵ b Tested by a microbroth dilution method.

    • ↵ c Daptomycin therapy started 9 January 2004.

    • ↵ d Daptomycin therapy started 13 March 2004.

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Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus
M. K. Hayden, K. Rezai, R. A. Hayes, K. Lolans, J. P. Quinn, R. A. Weinstein
Journal of Clinical Microbiology Oct 2005, 43 (10) 5285-5287; DOI: 10.1128/JCM.43.10.5285-5287.2005

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Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus
M. K. Hayden, K. Rezai, R. A. Hayes, K. Lolans, J. P. Quinn, R. A. Weinstein
Journal of Clinical Microbiology Oct 2005, 43 (10) 5285-5287; DOI: 10.1128/JCM.43.10.5285-5287.2005
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KEYWORDS

Anti-Bacterial Agents
daptomycin
Drug Resistance, Bacterial
methicillin resistance
Staphylococcus aureus

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