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Mycology

In Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole

M. A. Pfaller, L. Boyken, R. J. Hollis, S. A. Messer, S. Tendolkar, D. J. Diekema
M. A. Pfaller
1Departments of Pathology
2Epidemiology
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  • For correspondence: michael-pfaller@uiowa.edu
L. Boyken
1Departments of Pathology
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R. J. Hollis
1Departments of Pathology
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S. A. Messer
1Departments of Pathology
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S. Tendolkar
1Departments of Pathology
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D. J. Diekema
1Departments of Pathology
3Medicine, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242
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DOI: 10.1128/JCM.43.11.5425-5427.2005
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Tables

  • TABLE 1.

    Species distribution of Candida isolates by geographic region

    Species% by regiona
    APAC (354 isolates)LAM (542 isolates)EU (668 isolates)NAM (671 isolates)Total (2,235 isolates)
    C. albicans 56.244.361.749.252.8
    C. tropicalis 16.120.88.47.712.4
    C. parapsilosis 15.318.110.915.414.7
    C. glabrata 8.04.810.221.311.9
    C. krusei 1.11.65.21.62.6
    C. guilliermondii 1.47.60.90.82.6
    C. lusitaniae 1.10.61.13.01.5
    C. kefyr 0.61.30.40.7
    Candida spp.b0.81.60.30.60.8
    • ↵ a Regions: APAC, Asia-Pacific (16 study sites); LAM, Latin America (15 study sites); EU, Europe (32 study sites); NAM, North America (28 study sites).

    • ↵ b Includes C. famata (8 isolates), C. dubliniensis (4 isolates), C. lipolytica (2 isolates), and C. rugosa (2 isolates).

  • TABLE 2.

    In vitro susceptibilities of 2,235 clinical isolates of Candida spp. to anidulafungina

    OrganismNo. testedCumulative % susceptible at:
    0.007 μg/ml0.015 μg/ml0.03 μg/ml0.06 μg/ml0.12 μg/ml0.25 μg/ml0.5 μg/ml1 μg/ml2 μg/ml4 μg/ml8 μg/ml
    C. albicans 1,181428618899999999100
    C. glabrata 2651197097100
    C. tropicalis 278125729498999999100
    C. krusei 5956495100
    C. kefyr 15767100
    C. parapsilosis 3281111263997100
    C. guilliermondii 572596093100
    C. lusitaniae 34125997100
    Candida spp.18613132531569494100
    Total2,2352184570808283899999100
    • ↵ a Broth microdilution testing according to CLSI M27-A2 (10), using 24-h incubation and MIC-2 endpoint.

  • TABLE 3.

    In vitro activity of anidulafungin against 315 fluconazole-resistant clinical isolates of Candida spp.a

    OrganismNo. testedCumulative % susceptible to anidulafungin at:
    0.007 μg/ml0.015 μg/ml0.03 μg/ml0.06 μg/ml0.12 μg/ml0.25 μg/ml0.5 μg/ml1 μg/ml2 μg/ml4 μg/ml8 μg/ml
    C. albicans 4115426695959598100
    C. glabrata 11013368198100
    C. krusei 1461340829799100
    Candida spp.18617393939446783100
    Total31539428194969899100
    • ↵ a Broth microdilution testing was done according to CLSI M27-A2 (10), using 24-h incubation and MIC-2 endpoint. Fluconazole resistance is defined as a MIC of ≥64 μg/ml.

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In Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole
M. A. Pfaller, L. Boyken, R. J. Hollis, S. A. Messer, S. Tendolkar, D. J. Diekema
Journal of Clinical Microbiology Nov 2005, 43 (11) 5425-5427; DOI: 10.1128/JCM.43.11.5425-5427.2005

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In Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole
M. A. Pfaller, L. Boyken, R. J. Hollis, S. A. Messer, S. Tendolkar, D. J. Diekema
Journal of Clinical Microbiology Nov 2005, 43 (11) 5425-5427; DOI: 10.1128/JCM.43.11.5425-5427.2005
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KEYWORDS

antifungal agents
Candida
fluconazole
Microbial Sensitivity Tests
Peptides, Cyclic

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