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Journal of Clinical Microbiology
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Epidemiology

Outbreak of Infection Caused by Enterobacter cloacae Producing the Novel VEB-3 Beta-Lactamase in China

Xiaofei Jiang, Yuxing Ni, Yanqun Jiang, Feiyi Yuan, Lizhong Han, Ming Li, Hong Liu, Li Yang, Yuan Lu
Xiaofei Jiang
1Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University
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Yuxing Ni
2Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University
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Yanqun Jiang
3Department of Clinical Laboratory of the Sixth People's Hospital of Shanghai, Shanghai, People's Republic of China
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Feiyi Yuan
1Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University
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Lizhong Han
2Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University
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Ming Li
1Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University
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Hong Liu
1Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University
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Li Yang
2Department of Clinical Microbiology, Rijin Hospital, Shanghai Second Medical University
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Yuan Lu
1Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University
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  • For correspondence: yuanlu@hsh.stn.sh.cn
DOI: 10.1128/JCM.43.2.826-831.2005
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ABSTRACT

Over a 4-month period from November 2002 to February 2003, 27 ceftazidime-resistant or cefotaxime-resistant nonrepetitive Enterobacter cloacae isolates were collected from 27 patients hospitalized at HuaShan Hospital, Shanghai, People's Republic of China. The Etest did not detect extended-spectrum beta-lactamases (ESBLs) in those 27 isolates; however, screening by the NCCLS ESBL disk test and confirmatory tests detected ESBLs in 4 of 27 isolates and PCR detected ESBLs in 23 of 27 isolates. The majority of ESBL producers exhibited the same repetitive extragenic palindromic PCR pattern but harbored different ESBL genes. CTX-M-3 was the most prevalent ESBL in our study. Interestingly, 12 clonally related E. cloacae isolates possessed a novel blaVEB-type beta-lactamase, blaVEB-3. BlaVEB-3 was encoded by the chromosome and was located in an integron. Nine of the 12 isolates harbored both the blaVEB-3 and the blaCTX-M-3-like ESBLs. This is the first report of a VEB-1-like ESBL in China and the first report of the simultaneous presence of VEB-1 and CTX-M-3-like ESBLs in an isolate.

  • Copyright © 2005 American Society for Microbiology
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Outbreak of Infection Caused by Enterobacter cloacae Producing the Novel VEB-3 Beta-Lactamase in China
Xiaofei Jiang, Yuxing Ni, Yanqun Jiang, Feiyi Yuan, Lizhong Han, Ming Li, Hong Liu, Li Yang, Yuan Lu
Journal of Clinical Microbiology Feb 2005, 43 (2) 826-831; DOI: 10.1128/JCM.43.2.826-831.2005

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Outbreak of Infection Caused by Enterobacter cloacae Producing the Novel VEB-3 Beta-Lactamase in China
Xiaofei Jiang, Yuxing Ni, Yanqun Jiang, Feiyi Yuan, Lizhong Han, Ming Li, Hong Liu, Li Yang, Yuan Lu
Journal of Clinical Microbiology Feb 2005, 43 (2) 826-831; DOI: 10.1128/JCM.43.2.826-831.2005
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KEYWORDS

Cross Infection
Disease Outbreaks
Enterobacter cloacae
Enterobacteriaceae Infections
beta-lactamases

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