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Journal of Clinical Microbiology
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Mycology

Detection of Aspergillus fumigatus and a Mutation That Confers Reduced Susceptibility to Itraconazole and Posaconazole by Real-Time PCR and Pyrosequencing

Jason P. Trama, Eli Mordechai, Martin E. Adelson
Jason P. Trama
Medical Diagnostic Laboratories, L.L.C., Hamilton, New Jersey
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Eli Mordechai
Medical Diagnostic Laboratories, L.L.C., Hamilton, New Jersey
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Martin E. Adelson
Medical Diagnostic Laboratories, L.L.C., Hamilton, New Jersey
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  • For correspondence: madelson@mdlab.com
DOI: 10.1128/JCM.43.2.906-908.2005
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ABSTRACT

A real-time PCR and pyrosequencing method was developed to detect Aspergillus fumigatus in whole blood by amplifying the cyp51A gene and sequencing the codon for glycine 54. Mutations in this codon can result in amino acid substitutions that confer reduced susceptibility to itraconazole and posaconazole.

  • Copyright © 2005 American Society for Microbiology
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Detection of Aspergillus fumigatus and a Mutation That Confers Reduced Susceptibility to Itraconazole and Posaconazole by Real-Time PCR and Pyrosequencing
Jason P. Trama, Eli Mordechai, Martin E. Adelson
Journal of Clinical Microbiology Feb 2005, 43 (2) 906-908; DOI: 10.1128/JCM.43.2.906-908.2005

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Detection of Aspergillus fumigatus and a Mutation That Confers Reduced Susceptibility to Itraconazole and Posaconazole by Real-Time PCR and Pyrosequencing
Jason P. Trama, Eli Mordechai, Martin E. Adelson
Journal of Clinical Microbiology Feb 2005, 43 (2) 906-908; DOI: 10.1128/JCM.43.2.906-908.2005
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KEYWORDS

antifungal agents
Aspergillus fumigatus
Cytochrome P-450 Enzyme System
Drug Resistance, Fungal
Fungal Proteins
itraconazole
mutation
Triazoles

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