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Journal of Clinical Microbiology
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Virology

Diagnosis of and Screening for Cytomegalovirus Infection in Pregnant Women

S. C. Munro, B. Hall, L. R. Whybin, L. Leader, P. Robertson, G. T. Maine, W. D. Rawlinson
S. C. Munro
1Virology Division
2School of Biotechnology and Biomolecular Sciences
3School of Medical Sciences, University of New South Wales, Kensington, New South Wales, Australia
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  • For correspondence: smunro@ctc.usyd.edu.au
B. Hall
1Virology Division
4Royal Hospital for Women, Randwick, New South Wales, Australia
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L. R. Whybin
5Serology Laboratory, Department of Microbiology, SEALS Prince of Wales Hospital, Randwick, New South Wales, Australia
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L. Leader
4Royal Hospital for Women, Randwick, New South Wales, Australia
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P. Robertson
5Serology Laboratory, Department of Microbiology, SEALS Prince of Wales Hospital, Randwick, New South Wales, Australia
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G. T. Maine
6Core Research and Development, Abbott Laboratories Diagnostic Division, Abbott Park, Illinois
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W. D. Rawlinson
1Virology Division
2School of Biotechnology and Biomolecular Sciences
3School of Medical Sciences, University of New South Wales, Kensington, New South Wales, Australia
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DOI: 10.1128/JCM.43.9.4713-4718.2005
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    FIG. 1.

    Proposed diagnostic algorithm for CMV serology screening in pregnant women.

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  • TABLE 1.

    Serological data collected prospectively between 7 October 2002 and 1 June 2004 for 600 pregnant womena

    CMV immunoglobulin statusNo. of women at:Total no. of women examined
    IgGIgMIgG avidity≤20 weeks gestation>20 weeks gestation
    −−ND16990259
    +−ND202106308
    ++Low527
    ++High20626
    • ↵ a +, positive; −, negative; ND, not done; low, <35%; high, ≥35%.

  • TABLE 2.

    Screening data from seven women diagnosed as being at high risk for CMV intrauterine transmissiona

    CaseGestation at testing (wk)GroupCMV IgGCMV IgM (AxSYM)CMV IgM (Eti-Cytok)CMV IgG avidity (%)PCRCMV status at birth
    UrineBlood
    17A+++22−+Uninfected
    212A+++33+−Not tested
    311A++−23−+Uninfected
    414A++−33−−Uninfected
    512A+++29+−Uninfected
    628B+++10−+Infected
    731B+++27++Infected
    • ↵ a +, positive; −, negative.

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Diagnosis of and Screening for Cytomegalovirus Infection in Pregnant Women
S. C. Munro, B. Hall, L. R. Whybin, L. Leader, P. Robertson, G. T. Maine, W. D. Rawlinson
Journal of Clinical Microbiology Sep 2005, 43 (9) 4713-4718; DOI: 10.1128/JCM.43.9.4713-4718.2005

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Diagnosis of and Screening for Cytomegalovirus Infection in Pregnant Women
S. C. Munro, B. Hall, L. R. Whybin, L. Leader, P. Robertson, G. T. Maine, W. D. Rawlinson
Journal of Clinical Microbiology Sep 2005, 43 (9) 4713-4718; DOI: 10.1128/JCM.43.9.4713-4718.2005
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KEYWORDS

Antibodies, Viral
cytomegalovirus
Cytomegalovirus Infections
Mass Screening
Pregnancy Complications, Infectious
Prenatal Diagnosis

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