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Virology

Early Detection of Hepatitis C Virus Infection by Use of a New Combined Antigen-Antibody Detection Assay: Potential Use for High-Risk Individuals

A. Schnuriger, S. Dominguez, M.-A. Valantin, R. Tubiana, C. Duvivier, J. Ghosn, A. Simon, C. Katlama, V. Thibault
A. Schnuriger
1Virology
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S. Dominguez
2Infectious Diseases
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M.-A. Valantin
2Infectious Diseases
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R. Tubiana
2Infectious Diseases
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C. Duvivier
2Infectious Diseases
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J. Ghosn
2Infectious Diseases
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A. Simon
3Internal Medicine Departments, Pitié-Salpêtrière Hospital, Paris, France
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C. Katlama
2Infectious Diseases
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V. Thibault
1Virology
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  • For correspondence: vincent.thibault@psl.aphp.fr
DOI: 10.1128/JCM.44.4.1561-1563.2006
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Tables

  • TABLE 1.

    HIV and HCV infection characteristics and performances of the Ag-Ab assay expressed as delays of HCV infection detection compared to those by reference methods

    Patient no.Age (yr)HIV viral load (no. of copies/ml)aCD4 count (no. of cells/mm3)First positive HCV PCR result (log10 IU/ml)HCV genotypeTime (days) to resultb
    PCR, AbPCR, Ag-AbAg-Ab, Ab
    Threshold 1Threshold 0.5Threshold 1Threshold 0.5
    146<2006686.754d85008585
    250<2006704.653a32262666
    339<2006816.081a10000100100
    435<200389>6.893a37902837
    55039,0004105.974d00000
    642<2006185.64200000
    755<2002276.063a50055
    847<2003945.943a78007878
    953<2003226.443a00000
    1051<200514>6.891a13113100131
    1138<506576.674−c−0−−
    12482384786.814d62006262
    1353<208014.483949418076
    1451<200214>6.894d10600106106
    1531<2001876.094d14899049148
    1634<2004086.84414300143143
    1756<200582>6.894d89008989
    18611,960355<2.781a12612612600
    194675,9004396.71156005656
    20312,5706606.49493009393
    Total47d200d478d6.58d77e27e9e50e68e
    • ↵ a At presentation.

    • ↵ b PCR, first positive HCV RNA detection; Ab, first positive detection by Monolisa anti-HCV Plus V2; Ag-Ab, first positive detection by Monolisa HCV Ag-Ab Ultra.

    • ↵ c −, no seroconversion.

    • ↵ d Median.

    • ↵ e Mean.

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Early Detection of Hepatitis C Virus Infection by Use of a New Combined Antigen-Antibody Detection Assay: Potential Use for High-Risk Individuals
A. Schnuriger, S. Dominguez, M.-A. Valantin, R. Tubiana, C. Duvivier, J. Ghosn, A. Simon, C. Katlama, V. Thibault
Journal of Clinical Microbiology Apr 2006, 44 (4) 1561-1563; DOI: 10.1128/JCM.44.4.1561-1563.2006

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Early Detection of Hepatitis C Virus Infection by Use of a New Combined Antigen-Antibody Detection Assay: Potential Use for High-Risk Individuals
A. Schnuriger, S. Dominguez, M.-A. Valantin, R. Tubiana, C. Duvivier, J. Ghosn, A. Simon, C. Katlama, V. Thibault
Journal of Clinical Microbiology Apr 2006, 44 (4) 1561-1563; DOI: 10.1128/JCM.44.4.1561-1563.2006
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KEYWORDS

Hepacivirus
hepatitis C
immunoassay

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