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Journal of Clinical Microbiology
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Bacteriology

Microevolution of Helicobacter pylori Type IV Secretion Systems in an Ulcer Disease Patient over a Ten-Year Period

Ayesha Alvi, S. Manjulata Devi, Irshad Ahmed, M. Abid Hussain, Mohammed Rizwan, Hérve Lamouliatte, Francis Mégraud, Niyaz Ahmed
Ayesha Alvi
1Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
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S. Manjulata Devi
1Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
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Irshad Ahmed
2Deccan College of Medical Sciences and Allied Hospitals, Hyderabad, India
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M. Abid Hussain
1Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
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Mohammed Rizwan
1Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
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Hérve Lamouliatte
3Service Hépato-Gastroentérologie, Hôpital Saint André, Bordeaux, France
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Francis Mégraud
4ISOGEM Working Group on Genetics of Helicobacters, International Society for Genomic and Evolutionary Microbiology (ISOGEM), Sassari, Italy
5INSERM U853 and Université Victor Segalen Bordeaux 2, Laboratoire de Bactériologie, 33076 Bordeaux, France
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Niyaz Ahmed
1Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India
4ISOGEM Working Group on Genetics of Helicobacters, International Society for Genomic and Evolutionary Microbiology (ISOGEM), Sassari, Italy
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  • For correspondence: niyaz@cdfd.org.in
DOI: 10.1128/JCM.01631-07
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ABSTRACT

Helicobacter pylori cagA and vacA genotypes have been used for almost a decade as stable entities to link the severity of gastritis and ulcer disease. We describe here microevolution of the two genomic islands, cag pathogenicity island (cagPAI; 40 kb) and tfs3 (16 kb) from isolates obtained at inclusion (one subclone) and after a 10-year period (two subclones) from a duodenal ulcer patient. Our results indicate microevolution in cagA, cagE, and cag7 genes of the cagPAI and open reading frames G, P, and L in tfs3, which possibly leads to inactivation or pseudogenization of these genes. Interestingly, no significant reduction in the severity of gastroduodenal pathology was found. These results point to an obvious difficulty in correlating the continuously evolving virulence factors such as the cagPAI genes with disease characteristics that appear to remain stable.

  • Copyright © 2007 American Society for Microbiology
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Microevolution of Helicobacter pylori Type IV Secretion Systems in an Ulcer Disease Patient over a Ten-Year Period
Ayesha Alvi, S. Manjulata Devi, Irshad Ahmed, M. Abid Hussain, Mohammed Rizwan, Hérve Lamouliatte, Francis Mégraud, Niyaz Ahmed
Journal of Clinical Microbiology Dec 2007, 45 (12) 4039-4043; DOI: 10.1128/JCM.01631-07

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Microevolution of Helicobacter pylori Type IV Secretion Systems in an Ulcer Disease Patient over a Ten-Year Period
Ayesha Alvi, S. Manjulata Devi, Irshad Ahmed, M. Abid Hussain, Mohammed Rizwan, Hérve Lamouliatte, Francis Mégraud, Niyaz Ahmed
Journal of Clinical Microbiology Dec 2007, 45 (12) 4039-4043; DOI: 10.1128/JCM.01631-07
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KEYWORDS

Evolution, Molecular
Helicobacter Infections
Helicobacter pylori
Peptic Ulcer

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