Article Figures & Data
Tables
- TABLE 1.
Species distribution of Candida isolates by geographic region
Candida species % of isolatesa APAC (n = 958) LAM (n = 1,112) EU (n = 1,787) NAM (n = 1,489) Total (n = 5,346) C. albicans 57.10 47.93 58.42 50.03 53.67 C. parapsilosis 15.97 18.62 10.63 14.04 14.20 C. glabrata 8.46 5.67 13.93 23.77 13.97 C. tropicalis 14.20 19.96 8.56 7.66 11.69 C. krusei 0.94 1.62 4.87 1.48 2.54 C. guilliermondii 0.73 3.60 0.50 0.34 1.14 C. lusitaniae 0.63 0.63 1.29 1.48 1.08 C. kefyr 0.10 0.63 1.23 0.47 0.69 C. famata 0.84 0.72 0.22 0.27 0.45 Candida spp.b 1.04 0.63 0.34 0.47 0.56 ↵ a Regions: APAC, Asia-Pacific (16 study sites); LAM, Latin America (15 study sites); EU, Europe (32 study sites); NAM, North America (28 study sites). For each region, the number of isolates (n) is given in parentheses.
↵ b Includes C. pelliculosa (11 isolates), C. lipolytica (8 isolates), C. dubliniensis (6 isolates), C. rugosa (2 isolates), C. zeylanoides (2 isolates), and C. intermedia (1 isolate).
- TABLE 2.
In vitro susceptibilities of 5,346 clinical isolates of Candida spp. to anidulafungin, caspofungin, and micafungin
Organism No. of isolates tested Antifungal agent Cumulative % of isolates susceptible at a MIC (μg/ml) ofa: 0.007 0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 ≥8 C. albicans 2,869 Anidulafungin 6.2 33.5 69.5 92.4 99.1 99.5 99.5 99.6 100.0 Caspofungin 1.7 26.7 74.2 97.1 99.3 99.9 100.0 Micafungin 11.9 80.6 96.4 99.3 99.4 99.5 99.6 100.0 C. parapsilosis 759 Anidulafungin 0.3 0.3 0.3 1.4 4.7 27.9 92.5 100.0 Caspofungin 0.1 0.5 3.3 10.7 52.2 89.5 98.6 99.9 100.0 Micafungin 0.1 0.3 0.3 0.5 6.1 24.4 79.3 100.0 C. glabrata 747 Anidulafungin 0.4 7.8 62.4 93.6 99.4 99.7 99.9 99.9 100.0 Caspofungin 7.0 65.2 95.3 98.4 99.2 99.7 99.9 99.9 99.9 100.0 Micafungin 13.7 91.4 97.9 98.9 99.5 99.9 99.9 100.0 C. tropicalis 625 Anidulafungin 3.2 24.2 75.7 95.0 98.4 99.4 99.5 99.5 100.0 Caspofungin 1.3 31.0 79.7 97.3 99.0 99.7 99.7 99.8 99.8 99.8 100.0 Micafungin 4.0 39.5 77.6 96.3 98.6 99.5 99.7 100.0 C. krusei 136 Anidulafungin 2.9 47.1 90.4 99.3 99.3 100.0 Caspofungin 0.7 0.7 41.9 75.7 94.9 99.3 100.0 Micafungin 2.2 13.2 85.3 96.3 100.0 C. guilliermondii 61 Anidulafungin 3.3 6.6 13.1 57.4 90.2 100.0 Caspofungin 1.6 4.9 11.5 39.3 80.3 95.1 95.1 95.1 100.0 Micafungin 3.3 3.3 6.6 11.5 21.3 65.6 98.4 100.0 C. lusitaniae 58 Anidulafungin 1.7 13.8 43.1 96.6 100.0 Caspofungin 3.4 6.9 44.8 89.7 96.6 100.0 Micafungin 1.7 8.6 63.8 96.6 98.3 100.0 C. kefyr 37 Anidulafungin 2.7 10.8 56.8 100.0 Caspofungin 13.5 97.3 100.0 Micafungin 5.4 40.5 100.0 C. famata 24 Anidulafungin 4.2 16.7 20.8 20.8 20.8 25.0 50.0 100.0 Caspofungin 4.2 12.5 20.8 37.5 70.8 70.8 95.8 100.0 Micafungin 4.2 16.7 16.7 20.8 33.3 75.0 91.7 100.0 Candida spp. 30 Anidulafungin 3.3 30.0 50.0 63.3 63.3 73.3 86.7 93.3 96.7 96.7 100.0 Caspofungin 16.7 43.3 63.3 73.3 96.7 100.0 Micafungin 20.0 53.3 66.7 66.7 86.7 100.0 Total 5,346 Anidulafungin 3.7 21.1 48.9 72.6 82.0 83.4 84.7 88.7 98.8 99.9 100.0 Caspofungin 1.2 19.7 59.4 79.6 84.0 91.9 98.1 99.7 99.9 99.9 100.0 Micafungin 8.8 60.9 75.6 81.9 83.3 85.0 88.5 97.0 100.0 ↵ a Values corresponding to MICs at which at least 90% of isolates are inhibited are listed in bold type.
- TABLE 3.
Variation in echinocandin MIC profiles by geographic region
Region(s) and species No. of isolates tested Antifungal agent No. of isolates for which the MIC (μg/ml) was: 0.007 0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 ≥8 Asia-Pacific C. albicans 547 Anidulafungin 32 136 195 128 49 4 1 2 Caspofungin 12 139 228 148 16 3 1 Micafungin 63 351 108 21 2 2 C. parapsilosis 153 Anidulafungin 1 1 5 44 96 6 Caspofungin 1 6 9 65 55 9 8 Micafungin 1 5 34 91 22 C. glabrata 81 Anidulafungin 6 55 18 2 Caspofungin 8 56 16 1 Micafungin 16 55 8 2 C. tropicalis 136 Anidulafungin 5 26 67 34 4 Caspofungin 2 48 58 24 3 1 Micafungin 7 38 60 23 5 3 C. krusei 9 Anidulafungin 4 5 Caspofungin 7 2 Micafungin 1 6 2 C. guilliermondii 7 Anidulafungin 1 1 4 1 Caspofungin 1 2 3 1 Micafungin 1 1 3 2 C. lusitaniae 6 Anidulafungin 2 3 1 Caspofungin 3 3 Micafungin 1 4 1 C. kefyr 1 Anidulafungin 1 Caspofungin 1 Micafungin 1 C. famata 8 Anidulafungin 1 1 2 4 Caspofungin 1 1 1 4 1 Micafungin 2 3 1 2 Latin America C. albicans 533 Anidulafungin 34 134 185 134 42 2 2 Caspofungin 7 119 249 134 19 5 Micafungin 57 363 88 23 2 C. parapsilosis 207 Anidulafungin 1 2 10 61 123 10 Caspofungin 2 5 24 81 77 16 1 1 Micafungin 1 1 19 50 109 27 C. glabrata 63 Anidulafungin 8 42 12 1 Caspofungin 4 37 18 4 Micafungin 8 53 2 C. tropicalis 222 Anidulafungin 5 39 119 47 6 5 1 Caspofungin 2 61 110 42 5 2 Micafungin 6 79 91 39 4 2 1 C. krusei 18 Anidulafungin 9 8 1 Caspofungin 6 7 5 Micafungin 1 15 2 C. guilliermondii 40 Anidulafungin 2 3 20 10 5 Caspofungin 1 4 10 17 5 3 Micafungin 4 2 18 15 1 C. lusitaniae 7 Anidulafungin 3 4 Caspofungin 2 3 2 Micafungin 5 2 C. kefyr 7 Anidulafungin 2 3 2 Caspofungin 7 Micafungin 4 3 C. famata 8 Anidulafungin 1 2 5 Caspofungin 1 1 1 4 1 Micafungin 2 4 2 Europe C. albicans 1,044 Anidulafungin 47 268 399 268 56 1 1 4 Caspofungin 12 238 534 230 25 4 1 Micafungin 108 748 155 25 3 1 4 C. parapsilosis 190 Anidulafungin 4 3 40 124 19 Caspofungin 1 5 11 71 79 22 1 Micafungin 1 7 26 111 45 C. glabrata 249 Anidulafungin 1 14 135 91 7 1 Caspofungin 17 146 69 14 3 Micafungin 28 199 18 3 1 C. tropicalis 153 Anidulafungin 7 33 87 19 5 1 1 Caspofungin 3 48 74 24 3 1 Micafungin 8 60 53 28 3 1 C. krusei 87 Anidulafungin 3 38 36 9 1 Caspofungin 1 32 31 18 4 1 Micafungin 2 12 60 9 4 C. guilliermondii 9 Anidulafungin 1 1 3 4 Caspofungin 1 3 3 2 Micafungin 1 1 1 4 2 C. lusitaniae 23 Anidulafungin 1 2 6 13 1 Caspofungin 2 7 11 1 2 Micafungin 1 1 10 10 1 C. kefyr 22 Anidulafungin 1 10 11 Caspofungin 2 19 1 Micafungin 6 16 C. famata 4 Anidulafungin 2 1 1 Caspofungin 2 1 1 Micafungin 1 1 2 North America C. albicans 745 Anidulafungin 64 246 254 128 43 5 1 4 Caspofungin 18 220 354 145 4 3 1 Micafungin 114 508 102 14 2 2 3 C. parapsilosis 209 Anidulafungin 2 7 31 147 22 Caspofungin 5 12 98 72 22 Micafungin 11 29 106 63 C. glabrata 354 Anidulafungin 2 27 176 132 14 2 1 Caspofungin 23 196 122 4 3 4 1 1 Micafungin 50 274 20 6 1 2 1 C. tropicalis 114 Anidulafungin 3 33 49 21 6 2 Caspofungin 1 29 62 20 1 1 Micafungin 4 45 34 27 2 1 1 C. krusei 22 Anidulafungin 1 9 10 2 Caspofungin 11 6 3 2 Micafungin 1 1 17 2 1 C. guilliermondii 5 Anidulafungin 3 2 Caspofungin 2 2 1 Micafungin 2 2 1 C. lusitaniae 22 Anidulafungin 3 5 13 1 Caspofungin 2 10 9 1 Micafungin 2 13 6 1 C. kefyr 7 Anidulafungin 1 4 2 Caspofungin 3 4 Micafungin 2 3 2 C. famata 4 Anidulafungin 1 1 2 Caspofungin 1 2 1 Micafungin 1 1 1 1