DOI: 10.1128/JCM.00506-08
Article Figures & Data
Tables
- TABLE 1.
Demographic characteristics of case patients and negative control patients by infection type
Characteristic No. (%) of patientsa Aspergillosis (n = 22) Candida infection (n = 23) Other mold infection (n = 17) Gender No. of males 16 (73) 12 (52) 9 (53) No. of females 6 (27) 11 (48) 8 (47) Age (yr) (median [range]) 60 (10-78) 55 (23-81) 51 (22-73) Underlying disease Hematological 22 (100) 11 (48) 17 (100) Solid tumor 0 (0) 12 (52) 0 (0) Bone marrow transplantation 12 (55) 2 (9) 9 (53) Allogeneic hematopoietic stem cell transplant donor type 12 (55) 2 (9) 7 (41) Site of IFI Lung 21 (96) 4 (23) Sinus 1 (5) 5 (29) Blood 23 (100) 2 (12) Skin 6 (35) Antifungal therapy 22 (100) 21 (91) 17 (100) Graft-versus-host disease 8 (36) 1 (4) 5 (29) Neutropenia during prior mo 12 (55) 9 (39) 9 (53) Neutropenia at infection onset 5 (23) 6 (26) 6 (35) Use of steroids before infection 15 (68) 9 (39) 11 (65) Use of steroids during infection 17 (77) 9 (39) 11 (65) Immunotherapy 18 (82) 10 (44) 13 (77) White blood cell count 2 (9) 2 (9) 4 (24) Granulocyte-macrophage colony-stimulating factor 4 (18) 2 (9) 4 (24) Granulocyte colony-stimulating factor 16 (73) 9 (39) 12 (71) Gamma interferon 1 (5) 1 (4) 6 (35) Breakthrough 20 (91) 11 (48) 13 (77) ↵ a Data represent numbers (percentages) of patients except where otherwise indicated.
- TABLE 2.
Performances of diagnostic tests for patients with IFI (per sample and per patient)
Type of comparison and IFI Assay Sensitivity (%) Specificity (%) PPV (%)a NPV (%)a Per sample Aspergillosis (n = 116) GM 24 99 97 57 BG 58 88 83 67 Candidemia (n = 102) GM 2 99 67 54 BG 61 88 82 72 Other mold infection (n = 77) GM 6 99 83 62 BG 47 88 72 72 Per patient Aspergillosis (n = 22) GM 38 100 100 61 BG 67 90 88 72 Candidemia (n = 23) GM 0 100 NA 49 BG 62 90 87 69 Other mold infection (n = 17) GM 6 100 100 57 BG 63 90 83 75 ↵ a PPV, positive predictive value; NPV, negative predictive value.
- TABLE 3.
Performances of GM enzyme immunoassay and BG test for patients infected with different organisms (per sample)
Test and organism Sensitivity (%) Specificity (%) PPV (%)a NPV (%)a GM enzyme immunoassay A. fumigatus (n = 69) 13 99 90 66 Non-fumigatus Aspergillus species (n = 39) 49 99 95 86 Other mold (n = 77) 6 99 83 62 BG test A. fumigatus (n = 69) 61 88 75 79 Non-fumigatus Aspergillus species (n = 39) 64 88 64 88 Other mold (n = 76) 47 88 72 72 ↵ a PPV, positive predictive value; NPV, negative predictive value.