DOI: 10.1128/JCM.01096-09
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Tables
- TABLE 1.
Fluconazole and voriconazole MIC50s and MIC90s obtained with VK2, CLSI (24 h and 48 h), and Etest (24 h and 48 h)
Candida sp. (no. of isolates), azole, and method 24 h 48 h EAa (%) MIC range MIC50 MIC90 MIC range MIC50 MIC90 C. albicans (84) Fluconazole VK2 ≤1-≥64d ≤1 ≤1 CLSI <0.125-64 0.125 0.5 <0.125->64 0.5 2 98.8 Etest 0.094-128 0.25 0.38 0.094->256 0.625 2 89.3 Voriconazole VK2 ≤0.12-0.5 ≤0.12 ≤0.12 CLSI <0.03-1 0.03 0.125 <0.03-2 0.03 0.125 100 Etest 0.003-1 0.008 0.023 0.002-2 0.02 0.064 98.8 C. parapsilosis (22) Fluconazole VK2 ≤1 ≤1 ≤1 CLSI <0.125-8 0.125 0.5 <0.125-8 0.25 0.5 95.4 Etest 0.064-0.5 0.315 0.38 0.064-8 1 1.5 90.9 Voriconazole VK2 ≤0.12 ≤0.12 ≤0.12 CLSI <0.03-0.25 <0.03 <0.03 <0.03-0.25 <0.03 0.03 100 Etest 0.004-0.047 0.012 0.023 0.006-0.19 0.032 0.064 100 C. tropicalis (17) Fluconazole VK2 ≤1-2 ≤1 2 CLSI <0.125-2 0.25 0.5 0.125-2 0.5 2 100 Etest 0.5-2 1.5 1.5 0.38-6 1.5 3 64.7 Voriconazole VK2 ≤0.12 ≤0.12 ≤0.12 CLSI <0.03-0.06 0.03 0.06 0.03-0.25 0.06 0.125 100 Etest 0.016-0.094 0.047 0.094 0.012-0.25 0.094 0.19 100 Other Candida spp. (5)c Fluconazole VK2 ≤1-2 ≤1 ≤1 CLSI <0.125-0.5 0.125 0.125 <0.125-4 0.125 0.125 100 Etest 0.064-3 0.75 0.75 0.064-3 0.75 0.75 100 Voriconazole VK2 ≤0.12-≤0.12 ≤0.12 ≤0.12 CLSI <0.03-<0.03 <0.03 <0.03 <0.03-<0.03 <0.003 <0.003 100 Etest 0.004-0.094 0.023 0.023 0.004-0.094 0.023 0.023 100 C. glabrata (56) Fluconazole VK2 ≤1-≥64 8 32 CLSI <0.125-64 2 8 0.125->64 6 16 94.6 Etest 0.094->256 7 16 0.094->256 >256 >256 25 Voriconazole VK2 ≤0.12-≥8 ≤0.12 2 CLSI <0.03-8 0.125 0.5 0.03-8 0.125 2 89.3 Etest 0.016-8 0.125 1.5 0.032->32 1.5 32 32.1 C. inconspicua (5), C. norvegensis (2) Fluconazole VK2 4-≥64 16 16 CLSI <0.125-16 <0.125 <0.125 2-32 16 16 100 Etest 8-24 10 10 24->256 >256 >256 85.7 Voriconazole VK2 ≤0.12-0.25 ≤0.12 ≤0.12 CLSI <0.03-0.5 <0.03 <0.03 0.03-0.5 0.25 0.25 100 Etest 0.19-2 0.19 0.19 0.19-2 0.19 0.19 85.7 C. krusei (14) Fluconazole VK2 4-32 16 32 100/92.8b CLSI 0.25-64 16 32 8-64 32 64 100b Etest 32->256 >256 >256 Voriconazole VK2 ≤0.12-0.25 ≤0.12 0.25 CLSI 0.03-0.5 0.25 0.5 0.25-1 0.5 1 92.8 Etest 0.19-0.5 0.25 0.25 0.064-1.5 0.25 1.5 64.3 - TABLE 2.
Fluconazole and voriconazole susceptibilities of 205 Candida sp. isolates, CAs, and errors between VK2 and CLSI/Etest methods at 24 and 48 h
Species (no. of isolates), azole, and method % of isolates (24 h/48 h)a that were: % CA with VK2 (24 h/48 h)a No. of VK2 errors (24 h/48 h)a Susceptible SDD Resistant VME ME mE C. albicans (84) Fluconazole VK2 98.8 0 1.2 CLSI 98.8 0 1.2 100 0 0 0 Etest 98.8 0 1.2 100 0 0 0 Voriconazole VK2 100 0 0 CLSI 100/98.8 0/1.2 0 100/98.8 0 0 1 Etest 100/98.8 0/1.2 0 100/98.8 0 0 1 C. parapsilosis (22), C. tropicalis (17), other spp. (5)b Fluconazole + voriconazole VK2 100 0 0 CLSI 100 0 0 100 0 0 0 Etest 100 0 0 100 0 0 0 C. glabrata (56) Fluconazole VK2 75 16.1 8.9 CLSI 80.3 14.3 5.4 78.6 0 1 11 Etest 71.5/12.5 16/23.2 12.5/64.3 77.3/23.2 1/23 1/0 12/20 Voriconazole VK2 87.5 5.4 7.1 CLSI 89.3/85.7 7.2/10.7 3.5/3.6 89.3/87.5 0 0 4/5 Etest 89.3/48.2 7.2/10.7 3.5/41.1 89.2/51.8 0/20 1/0 5/7 C. inconspicua (5), C. norvegensis (2) Fluconazole VK2 42.85 42.85 14.3 CLSI 28.6 71.4 0 71.4 0 0 1/2 Etest 28.6/0 71.4/28.6 0/71.4 75/14.3 0/1 0 1/5 Voriconazole VK2 100 0 0 CLSI 100 0 0 100 0 0 0 Etest 100/85.7 0/14.3 0 100/85.7 0 0 0/1 C. krusei (14) Fluconazole VK2c 0 0 100 CLSI 35.7/7.1 57.1/64.3 7.1/28.6 7.1/28.6 0 5/1 8/9 Etest 0 7.1 92.9 92.9 0 0 1 Voriconazole VK2 100 0 0 CLSI 100 0 0 100 0 0 0 Etest 100/85.7 0/14.3 0 100/85.7 0 0 2 ↵a Interpretative results obtained at 48 h if different from results at 24 h for CLSI and Etest methods only.
↵b Two strains of C. lusitaniae, one strain of C. guilliermondii, one strain of C. kefyr, and one strain of C. dubliniensis.
↵c Interpretative values and errors based on Vitek 2 expert software expertise.
- TABLE 3.
Amphotericin B susceptibilities of the 205 Candida sp. isolates used in this study
Species (no. of isolates) and method % of isolates (48 h) with MIC (mg/liter) of: 24 h 48 h EAa (%) ≤1 >1 MIC range MIC50 MIC90 MIC range MIC50 MIC90 C. albicans (84) VK2 100 ≤0.25-1c 0.5 1 CLSI 98.8 1.2 0.125-1 0.5 0.5 0.25-2 1 1 98.8 Etest 100 0.094-0.38 0.094 0.19 0.016-0.5 0.125 0.25 29.8 C. parapsilosis (22) VK2 100 ≤0.25-1 0.5 0.5 CLSI 81.8 18.2 0.125-0.5 0.25 0.5 0.5-2 1 2 86.4 Etest 100 0.094-0.5 0.125 0.25 0.064-1 0.38 0.75 63.6 C. tropicalis (17) VK2 100 ≤0.25-0.5 0.5 0.5 CLSI 100 0.5-1 0.25 1 0.5-2 1 2 100 Etest 100 0.047-0.25 0.125 0.19 0.032-0.75 0.25 0.5 70.6 Other Candida spp. (5)b VK2 100 ≤0.25-0.5 0.5 0.5 CLSI 100 0.06-1 0.5 0.5 0.25-1 0.5 0.5 100 Etest 100 0.047-0.38 0.25 0.25 100 C. glabrata (56) VK2 94.6 5.4 ≤0.25-8 0.5 1 CLSI 89.3 10.7 0.125-2 0.5 1 0.25-2 1 1 98.2 Etest 98.2 1.8 0.016-1 0.25 0.5 0.023->32 0.38 0.75 73.2 C. inconspicua (5), C. norvegensis (2) VK2 100 ≤0.25-1 ≤0.25 ≤0.25 CLSI 100 0.03-1 0.125 0.125 0.25-1 0.25 0.25 100 Etest 100 0.016-0.75 0.064 0.064 100 C. krusei (14) VK2 92.9 7.1 0.5-2 0.5 1 CLSI 71.4 28.6 1-2 1 2 0.25-2 1 2 100 Etest 85.7 14.3 0.094-1 0.75 0.75 0.19-2 0.875 2 78.6