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Mycobacteriology and Aerobic Actinomycetes

Natural Occurrence of Horizontal Transfer of Mycobacterium avium- Specific Insertion Sequence IS1245 to Mycobacterium kansasii

Michelle Christiane da Silva Rabello, Rosangela Siqueira de Oliveira, Rosa Maria Silva, Sylvia Cardoso Leao
Michelle Christiane da Silva Rabello
1Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu, 862 3° Andar, Sao Paulo, SP, Brazil
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Rosangela Siqueira de Oliveira
2Setor de Micobacterias, Instituto Adolfo Lutz, Avenida Dr. Arnaldo, 355, Sao Paulo, SP, Brazil
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Rosa Maria Silva
1Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu, 862 3° Andar, Sao Paulo, SP, Brazil
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Sylvia Cardoso Leao
1Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, Rua Botucatu, 862 3° Andar, Sao Paulo, SP, Brazil
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  • For correspondence: sylvia.leao@unifesp.br
DOI: 10.1128/JCM.02256-09
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ABSTRACT

Mycobacterium kansasii carrying IS1245, a highly prevalent insertion sequence among Mycobacterium avium isolates, was detected in a mixed culture of M. avium and M. kansasii. The insertion sequence was stable and able to transpose by a replicative mechanism in M. kansasii. These findings may have significant implications for molecular diagnosis and treatment outcome.

  • Copyright © 2010 American Society for Microbiology
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Natural Occurrence of Horizontal Transfer of Mycobacterium avium- Specific Insertion Sequence IS1245 to Mycobacterium kansasii
Michelle Christiane da Silva Rabello, Rosangela Siqueira de Oliveira, Rosa Maria Silva, Sylvia Cardoso Leao
Journal of Clinical Microbiology May 2010, 48 (6) 2257-2259; DOI: 10.1128/JCM.02256-09

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Natural Occurrence of Horizontal Transfer of Mycobacterium avium- Specific Insertion Sequence IS1245 to Mycobacterium kansasii
Michelle Christiane da Silva Rabello, Rosangela Siqueira de Oliveira, Rosa Maria Silva, Sylvia Cardoso Leao
Journal of Clinical Microbiology May 2010, 48 (6) 2257-2259; DOI: 10.1128/JCM.02256-09
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KEYWORDS

DNA Transposable Elements
Gene Transfer, Horizontal
Mycobacterium avium
Mycobacterium kansasii

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