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Virology

Comparison of a Newly Developed Automated and Quantitative Hepatitis C Virus (HCV) Core Antigen Test with the HCV RNA Assay for Clinical Usefulness in Confirming Anti-HCV Results

Recep Kesli, Hakkı Polat, Yuksel Terzi, Muhammet Guzel Kurtoglu, Yavuz Uyar
Recep Kesli
1Konya Education and Research Hospital, Department of Microbiology, Konya, Turkey
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  • For correspondence: recepkesli@yahoo.com
Hakkı Polat
2Selcuk University Meram Medical School, Department of Internal Diseases, Konya, Turkey
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Yuksel Terzi
3Ondokuzmayis University Faculty of Art and Science, Department of Statistics, Samsun, Turkey
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Muhammet Guzel Kurtoglu
1Konya Education and Research Hospital, Department of Microbiology, Konya, Turkey
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Yavuz Uyar
4Refik Saydam National Public Health Agency, Virology Reference Laboratory, Ankara, Turkey
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DOI: 10.1128/JCM.05292-11
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    Fig. 1.

    Correlation between HCV Ag and HCV RNA concentrations. The levels of HCV Ag were highly correlated with those of HCV RNA by the Spearman rank correlation test (r = 0.864; P = 0.0001). x, HCV RNA; y, HCV Ag. The data on the axes are log scaled.

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    Fig. 2.

    In the cases in which HCV RNA was detected, the group classifications were arbitrarily made by use of HCV RNA levels of ≤105 and >105 IU/ml (groups A and B, respectively). Median HCV core Ag levels of those groups were 25 and 2848 fmol/liter, respectively, and there were significant differences between them (P = 0.0001).

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  • Table 1.

    Summary of HCV Ag, HCV RNA, and anti-HCV test results

    HCV Ag test resultNo. of samples with the following HCV RNA load (no. of anti-HCV-positive samples/total no.):
    Not detected<105 IU/ml>105 IU/mlTotal
    Nonreactive52 (38/52)6 (1/6)0 (0/0)58 (39/58)
    Reactive0 (0/0)104 (104/104)50 (50/50)154 (154/154)
        Total52 (38/52)110 (105/110)50 (50/50)212 (193/212)
  • Table 2.

    Performances of the HCV Ag and anti-HCV tests compared to the HCV-RNA assaya

    TestSensitivity (%)Specificity (%)PPV (%)NPV (%)Accuracy (%)No. of samples
    Total positiveFalse negativeFalse positive
    HCV Ag (Abbott)96.3 (93.3-99.2)100 (100-100)100 (100-100)89.7 (81.8-97.5)97.2 (93.4-100)16060
    Anti-HCV (Abbott)96.3 (93.3-99.2)26.9 (14.9-38.9)80.2 (74.6-85.8)70.0 (49.9-90.1)79.2 (74.9-82.4)160638
    • ↵a Values in parentheses are ranges. PPV, positive predictive value; NPV, negative predictive value.

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Comparison of a Newly Developed Automated and Quantitative Hepatitis C Virus (HCV) Core Antigen Test with the HCV RNA Assay for Clinical Usefulness in Confirming Anti-HCV Results
Recep Kesli, Hakkı Polat, Yuksel Terzi, Muhammet Guzel Kurtoglu, Yavuz Uyar
Journal of Clinical Microbiology Nov 2011, 49 (12) 4089-4093; DOI: 10.1128/JCM.05292-11

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Comparison of a Newly Developed Automated and Quantitative Hepatitis C Virus (HCV) Core Antigen Test with the HCV RNA Assay for Clinical Usefulness in Confirming Anti-HCV Results
Recep Kesli, Hakkı Polat, Yuksel Terzi, Muhammet Guzel Kurtoglu, Yavuz Uyar
Journal of Clinical Microbiology Nov 2011, 49 (12) 4089-4093; DOI: 10.1128/JCM.05292-11
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