DOI: 10.1128/JCM.01824-10
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- Table 1.
The novel Clostridium difficile diagnostic assay loop-mediated isothermal amplification (LAMP; Illumigene) compared to cell culture cytotoxin B (CTBA) and/or toxigenic culture (TC) as the gold standarda
Diagnostic assay Diagnostic assay compared to CTBA plus TC Sensitivity Specificity PPV NPV % (no. of specimens/total no.) CI (%) % (no. of specimens/total no.) CI (%) % (no. of specimens/total no.) CI (%) % (no. of specimens/total no.) CI (%) LAMP 98 (49/50) 89–100 98 (218/222) 95–99 92 (49/53) 82–98 99 (218/219) 97–100 CTBA 72 (36/50) 57–84 100 (222/222) 98–100 100 (36/36) 90–100 94 (222/236) 90–97 TC 100 (50/50) 93–100 100 (222/222) 98–100 100 (50/50) 93–100 100 (222/222) 98–100 ↵a One of the four specimens that tested positive by LAMP only was positive in an in-house rpoA PCR, indicating that both the sensitivity and specificity of the LAMP test are higher. PPV, positive predictive value; NPV, negative predictive value; CI, confidence interval.
