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Virology

Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA

Yuki Moritou, Fusao Ikeda, Yasuto Takeuchi, Hiroyuki Seki, Shintaro Nanba, Yoshiaki Iwasaki, Kazuhide Yamamoto
A. M. Caliendo, Editor
Yuki Moritou
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Fusao Ikeda
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
bDepartment of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Yasuto Takeuchi
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Hiroyuki Seki
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Shintaro Nanba
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Yoshiaki Iwasaki
cHealth Service Center, Okayama University, Okayama, Japan
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Kazuhide Yamamoto
aDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
bDepartment of Molecular Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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A. M. Caliendo
Roles: Editor
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DOI: 10.1128/JCM.02792-13
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    FIG 1

    Clinical course and histology of patient 1. (A) Changes in serum HCV RNA and alanine aminotransferase. (B) Liver histology indicating liver cirrhosis (AZAN staining, 4-fold original magnification). (C) Immunohistochemical staining with a monoclonal antibody specific for HCV core demonstrating granular signal in the hepatocytes (400-fold original magnification).

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    FIG 2

    Sequence alignment of the HCV 5′ noncoding regions of various HCV genotypes and the patients in this study. The sequence of HCV-H77 (GenBank accession number AF009606) was used as a reference; position numbers are given at the top. Dots indicate identical nucleosides. Sequence alignment of HCV 5′ noncoding regions contains genotype 1a of HCV-1 (M62321) and HCV-H (M67463), genotype 1b of HCV-J (D90208) and HCV-N (AF139594), genotype 2a of JCH-1 (AB047640) and HC-J6 (D00944), genotype 2b of HCV-MA (AB030907) and HCV-J8 (D10988), and genotype 3a of HCV-NZL1 (D17763) and HCV-K3A (D28917). Sequences of patients 1 to 4 are aligned at the bottom.

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  • TABLE 1

    Characteristics of patients with serum HCV RNA levels that were undetectable by CAP/CTMa

    Patient characteristicPatient 1Patient 2Patient 3Patient 4
    Age (yr)49545456
    GenderMaleMaleMaleMale
    Liver histology (fibrosis/activity)d4/34/24/1Not done
    Alanine aminotransferase (IU/liter)124296251
    Platelet count (per mm3)89,00055,000134,000110,000
    Anti-HCV antibody (COI)b66.355.871.853.6
    HCV RNA with ARTc (log IU/ml)5.95.65.95.6
    HCV core antigen (fmol/liter)1,3403,3206231,586
    HCV genotype2a2a2a2a
    • ↵a CAP/CTM, Roche AmpliPrep/Cobas TaqMan HCV assay.

    • ↵b HCV, hepatitis C virus; COI, cutoff index.

    • ↵c ART, Abbott RealTime HCV assay.

    • ↵d Liver histology according to the criteria of Desmet et al. (8).

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Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA
Yuki Moritou, Fusao Ikeda, Yasuto Takeuchi, Hiroyuki Seki, Shintaro Nanba, Yoshiaki Iwasaki, Kazuhide Yamamoto
Journal of Clinical Microbiology Jan 2014, 52 (2) 544-548; DOI: 10.1128/JCM.02792-13

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Necessity for Reassessment of Patients with Serogroup 2 Hepatitis C Virus (HCV) and Undetectable Serum HCV RNA
Yuki Moritou, Fusao Ikeda, Yasuto Takeuchi, Hiroyuki Seki, Shintaro Nanba, Yoshiaki Iwasaki, Kazuhide Yamamoto
Journal of Clinical Microbiology Jan 2014, 52 (2) 544-548; DOI: 10.1128/JCM.02792-13
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