Article Figures & Data
Figures
- FIG 1
Clinical course and histology of patient 1. (A) Changes in serum HCV RNA and alanine aminotransferase. (B) Liver histology indicating liver cirrhosis (AZAN staining, 4-fold original magnification). (C) Immunohistochemical staining with a monoclonal antibody specific for HCV core demonstrating granular signal in the hepatocytes (400-fold original magnification).
- FIG 2
Sequence alignment of the HCV 5′ noncoding regions of various HCV genotypes and the patients in this study. The sequence of HCV-H77 (GenBank accession number AF009606) was used as a reference; position numbers are given at the top. Dots indicate identical nucleosides. Sequence alignment of HCV 5′ noncoding regions contains genotype 1a of HCV-1 (M62321) and HCV-H (M67463), genotype 1b of HCV-J (D90208) and HCV-N (AF139594), genotype 2a of JCH-1 (AB047640) and HC-J6 (D00944), genotype 2b of HCV-MA (AB030907) and HCV-J8 (D10988), and genotype 3a of HCV-NZL1 (D17763) and HCV-K3A (D28917). Sequences of patients 1 to 4 are aligned at the bottom.
Tables
- TABLE 1
Characteristics of patients with serum HCV RNA levels that were undetectable by CAP/CTMa
Patient characteristic Patient 1 Patient 2 Patient 3 Patient 4 Age (yr) 49 54 54 56 Gender Male Male Male Male Liver histology (fibrosis/activity)d 4/3 4/2 4/1 Not done Alanine aminotransferase (IU/liter) 124 29 62 51 Platelet count (per mm3) 89,000 55,000 134,000 110,000 Anti-HCV antibody (COI)b 66.3 55.8 71.8 53.6 HCV RNA with ARTc (log IU/ml) 5.9 5.6 5.9 5.6 HCV core antigen (fmol/liter) 1,340 3,320 623 1,586 HCV genotype 2a 2a 2a 2a
