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Bacteriology

Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant

Tommaso Giani, Fabio Arena, Guendalina Vaggelli, Viola Conte, Adriana Chiarelli, Lucia Henrici De Angelis, Rossella Fornaini, Maddalena Grazzini, Fabrizio Niccolini, Patrizia Pecile, Gian Maria Rossolini
K. C. Carroll, Editor
Tommaso Giani
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
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Fabio Arena
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
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Guendalina Vaggelli
bClinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
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Viola Conte
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
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Adriana Chiarelli
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
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Lucia Henrici De Angelis
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
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Rossella Fornaini
cHospital Pharmacy Unit, Florence Careggi University Hospital, Florence, Italy
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Maddalena Grazzini
dHospital Medical Direction, Florence Careggi University Hospital, Florence, Italy
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Fabrizio Niccolini
dHospital Medical Direction, Florence Careggi University Hospital, Florence, Italy
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Patrizia Pecile
bClinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
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Gian Maria Rossolini
aDepartment of Medical Biotechnologies, University of Siena, Siena, Italy
bClinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy
eDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy
fDon Carlo Gnocchi Foundation, Florence, Italy
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K. C. Carroll
Roles: Editor
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DOI: 10.1128/JCM.01017-15
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ABSTRACT

We describe a large hospital outbreak (93 bloodstream infections) of colistin-resistant Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates which was mirrored by increased colistin consumption. The outbreak was mostly traced to the clonal expansion of an mgrB deletion mutant of an ST512 strain that produced KPC-3.

  • Copyright © 2015, American Society for Microbiology. All Rights Reserved.
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Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant
Tommaso Giani, Fabio Arena, Guendalina Vaggelli, Viola Conte, Adriana Chiarelli, Lucia Henrici De Angelis, Rossella Fornaini, Maddalena Grazzini, Fabrizio Niccolini, Patrizia Pecile, Gian Maria Rossolini
Journal of Clinical Microbiology Sep 2015, 53 (10) 3341-3344; DOI: 10.1128/JCM.01017-15

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Large Nosocomial Outbreak of Colistin-Resistant, Carbapenemase-Producing Klebsiella pneumoniae Traced to Clonal Expansion of an mgrB Deletion Mutant
Tommaso Giani, Fabio Arena, Guendalina Vaggelli, Viola Conte, Adriana Chiarelli, Lucia Henrici De Angelis, Rossella Fornaini, Maddalena Grazzini, Fabrizio Niccolini, Patrizia Pecile, Gian Maria Rossolini
Journal of Clinical Microbiology Sep 2015, 53 (10) 3341-3344; DOI: 10.1128/JCM.01017-15
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