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Mycobacteriology and Aerobic Actinomycetes

Evaluation of the GenoType MTBDRsl Version 2.0 Assay for Second-Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa

Y. Gardee, A. W. Dreyer, H. J. Koornhof, S. V. Omar, P. da Silva, Z. Bhyat, N. A. Ismail
Geoffrey A. Land, Editor
Y. Gardee
aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
bDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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A. W. Dreyer
bDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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H. J. Koornhof
aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
bDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
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S. V. Omar
aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
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P. da Silva
bDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
dNational Health Laboratory Service, Mycobacterial Referral Laboratory, Braamfontein, Johannesburg, South Africa
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Z. Bhyat
aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
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N. A. Ismail
aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
cDepartment of Medical Microbiology, Faculty of Health Science, University of Pretoria, Pretoria, South Africa
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Geoffrey A. Land
Carter BloodCare & Baylor University Medical Center
Roles: Editor
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DOI: 10.1128/JCM.01865-16
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Article Information

DOI 
https://doi.org/10.1128/JCM.01865-16
PubMed 
27974543

Published By 
American Society for Microbiology Journals
History 
  • Received September 8, 2016
  • Returned for modification November 9, 2016
  • Accepted December 9, 2016
  • Published online February 22, 2017.

Copyright & Usage 
Copyright © 2017 American Society for Microbiology. All Rights Reserved .
Editors and / or Reviewers 
  • Geoffrey A. Land, Editor, Carter BloodCare & Baylor University Medical Center

Article Versions

  • Accepted Manuscript version (December 14, 2016).
  • You are viewing the most recent version of this article.

Author Information

  1. Y. Gardeea,b,
  2. A. W. Dreyerb,
  3. H. J. Koornhofa,b,
  4. S. V. Omara,
  5. P. da Silvab,d,
  6. Z. Bhyata and
  7. N. A. Ismaila,c
  1. aCentre for Tuberculosis, National Institute for Communicable Diseases, Johannesburg, South Africa
  2. bDepartment of Clinical Microbiology and Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  3. cDepartment of Medical Microbiology, Faculty of Health Science, University of Pretoria, Pretoria, South Africa
  4. dNational Health Laboratory Service, Mycobacterial Referral Laboratory, Braamfontein, Johannesburg, South Africa
  • Address correspondence to Y. Gardee, yasming{at}nicd.ac.za.
  • Citation Gardee Y, Dreyer AW, Koornhof HJ, Omar SV, da Silva P, Bhyat Z, Ismail NA. 2017. Evaluation of the genotype MTBDRsl version 2.0 assay for second-line drug resistance detection of Mycobacterium tuberculosis isolates in South Africa. J Clin Microbiol 55:791–800. https://doi.org/10.1128/JCM.01865-16 .

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Evaluation of the GenoType MTBDRsl Version 2.0 Assay for Second-Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa
Y. Gardee, A. W. Dreyer, H. J. Koornhof, S. V. Omar, P. da Silva, Z. Bhyat, N. A. Ismail
Journal of Clinical Microbiology Feb 2017, 55 (3) 791-800; DOI: 10.1128/JCM.01865-16

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Evaluation of the GenoType MTBDRsl Version 2.0 Assay for Second-Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa
Y. Gardee, A. W. Dreyer, H. J. Koornhof, S. V. Omar, P. da Silva, Z. Bhyat, N. A. Ismail
Journal of Clinical Microbiology Feb 2017, 55 (3) 791-800; DOI: 10.1128/JCM.01865-16
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KEYWORDS

Antitubercular Agents
Drug Resistance, Bacterial
Genotyping Techniques
Microbial Sensitivity Tests
Mycobacterium tuberculosis
GenoType MTBDRsl version 2.0
drug-resistant TB
MDR-TB
XDR-TB
line probe assay
LPA
fluoroquinolones
second-line injectable drugs
molecular diagnostic testing
phenotypic drug susceptibility testing
Mycobacterium tuberculosis

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