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Bacteriology

Prevalence of Fusobacterium necrophorum in Children Presenting with Pharyngitis

Tam T. Van, Laura M. Cox, Mike E. Cox, Jennifer Dien Bard
Peter Gilligan, Editor
Tam T. Van
aDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA
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Laura M. Cox
bDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
cAnaerobe Systems, Morgan Hill, California, USA
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Mike E. Cox
cAnaerobe Systems, Morgan Hill, California, USA
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Jennifer Dien Bard
aDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA
dKeck School of Medicine, University of Southern California, Los Angeles, California, USA
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Peter Gilligan
UNC Health Care System
Roles: Editor
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DOI: 10.1128/JCM.02174-16
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ABSTRACT

Fusobacterium necrophorum, an obligate anaerobic bacterium, was recently reported to be an important cause of bacterial pharyngitis with a prevalence as high as that of group A Streptococcus (GAS) in adolescents and young adults. Importantly, F. necrophorum is the primary causative agent of the life-threatening Lemierre's syndrome, and screening of pharyngeal samples may be warranted for its early detection and prevention. The aim of this study was to determine the prevalences of F. necrophorum and groups A and C/G streptococci as agents of bacterial pharyngitis in children. Pharyngeal samples (n = 300) were collected from pediatric patients presenting to the emergency department with signs and symptoms of pharyngitis. Overall, 10 (3.3%), 79 (26.3%), and 4 (1.3%) patients were PCR positive for F. necrophorum, GAS, and group C/G streptococci, respectively. The prevalence of F. necrophorum was significantly higher in patients between the ages of 14 and 20 years at 13.5% than in patients aged 14 years and younger (1.9%, P < 0.001). All positive patients presented with signs and symptoms similar to GAS pharyngitis. Our data demonstrated a potential role for F. necrophorum as a pathogen of pharyngitis among young adults, but suggests that the prevalence of F. necrophorum is low in preadolescent patients.

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Prevalence of Fusobacterium necrophorum in Children Presenting with Pharyngitis
Tam T. Van, Laura M. Cox, Mike E. Cox, Jennifer Dien Bard
Journal of Clinical Microbiology Mar 2017, 55 (4) 1147-1153; DOI: 10.1128/JCM.02174-16

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Prevalence of Fusobacterium necrophorum in Children Presenting with Pharyngitis
Tam T. Van, Laura M. Cox, Mike E. Cox, Jennifer Dien Bard
Journal of Clinical Microbiology Mar 2017, 55 (4) 1147-1153; DOI: 10.1128/JCM.02174-16
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KEYWORDS

Fusobacterium Infections
Fusobacterium necrophorum
pharyngitis
Fusobacterium
children
necrophorum
pediatric
pharyngitis

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