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Journal of Clinical Microbiology
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Minireview

CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests

Romney M. Humphries, Jane Ambler, Stephanie L. Mitchell, Mariana Castanheira, Tanis Dingle, Janet A. Hindler, Laura Koeth, Katherine Sei
Colleen Suzanne Kraft, Editor
Romney M. Humphries
aAccelerate Diagnostics, Tucson, Arizona, USA
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Jane Ambler
bWockhardt, Morton Grove Pharmaceuticals, Morton Grove, Illinois, USA
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Stephanie L. Mitchell
cClinical Microbiology Laboratory, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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Mariana Castanheira
dJMI Laboratories, North Liberty, Iowa, USA
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Tanis Dingle
eProvincial Laboratory for Public Health, Edmonton, Alberta, Canada
fDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
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Janet A. Hindler
gDepartment of Pathology & Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA
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Laura Koeth
hLaboratory Specialists, Inc., Westlake, Ohio, USA
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Katherine Sei
iBeckman-Coulter, West Sacramento, California, USA
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Colleen Suzanne Kraft
Emory University
Roles: Editor
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DOI: 10.1128/JCM.01934-17
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ABSTRACT

Effective evaluations of antimicrobial susceptibility tests (ASTs) require robust study design. The Clinical and Laboratory Standards Institute (CLSI) Subcommittee on Antimicrobial Susceptibility Testing has recognized that many published studies reporting the performance of commercial ASTs (cASTs) suffer from major design and/or analysis flaws, rendering the results difficult or impossible to interpret. This minireview outlines the current consensus of the Methods Development and Standardization Working Group of the CLSI Subcommittee on Antimicrobial Susceptibility Testing regarding best practices for systematic evaluation of the performance of an AST, including the analysis and presentation of essential data intended for publication.

FOOTNOTES

    • Accepted manuscript posted online 24 January 2018.
  • Supplemental material for this article may be found at https://doi.org/10.1128/JCM.01934-17.

  • Copyright © 2018 American Society for Microbiology.

All Rights Reserved.

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CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests
Romney M. Humphries, Jane Ambler, Stephanie L. Mitchell, Mariana Castanheira, Tanis Dingle, Janet A. Hindler, Laura Koeth, Katherine Sei on behalf of the CLSI Methods Development and Standardization Working Group of the Subcommittee on Antimicrobial Susceptibility Testing
Journal of Clinical Microbiology Mar 2018, 56 (4) e01934-17; DOI: 10.1128/JCM.01934-17

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CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests
Romney M. Humphries, Jane Ambler, Stephanie L. Mitchell, Mariana Castanheira, Tanis Dingle, Janet A. Hindler, Laura Koeth, Katherine Sei on behalf of the CLSI Methods Development and Standardization Working Group of the Subcommittee on Antimicrobial Susceptibility Testing
Journal of Clinical Microbiology Mar 2018, 56 (4) e01934-17; DOI: 10.1128/JCM.01934-17
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  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • STUDY DESIGN
    • EVALUATION OF RESULTS
    • QUALITY CONTROL
    • SUMMARY
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
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KEYWORDS

antimicrobial susceptibility testing
CLSI
evaluations

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