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Journal of Clinical Microbiology
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Bacteriology

Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis

Celia R. Walker, Kwana Lechiile, Margaret Mokomane, Andrew P. Steenhoff, Tonya Arscott-Mills, Jeffrey M. Pernica, David M. Goldfarb
Andrew B. Onderdonk, Editor
Celia R. Walker
Department of Pathology and Laboratory Medicine, BC Children’s Hospital, Vancouver, British Columbia, Canada
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Kwana Lechiile
Botswana-UPenn Partnership, Gaborone, Botswana
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Margaret Mokomane
University of Botswana, Gaborone, Botswana
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  • ORCID record for Margaret Mokomane
Andrew P. Steenhoff
Botswana-UPenn Partnership, Gaborone, BotswanaChildren’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Tonya Arscott-Mills
Botswana-UPenn Partnership, Gaborone, BotswanaChildren’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
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Jeffrey M. Pernica
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada
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David M. Goldfarb
Department of Pathology and Laboratory Medicine, BC Children’s Hospital, Vancouver, British Columbia, CanadaBotswana-UPenn Partnership, Gaborone, Botswana
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Andrew B. Onderdonk
Brigham and Women’s Hospital
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DOI: 10.1128/JCM.00962-19
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ABSTRACT

Diagnosing diarrheal disease is difficult in part due to challenges in obtaining and transporting a bulk stool specimen, particularly in resource-limited settings. We compared the performance of flocked rectal swabs to that of traditional bulk stool samples for enteric pathogen detection using the BioFire FilmArray gastrointestinal panel in children admitted to four hospitals in Botswana with community onset severe gastroenteritis. Of the 117-matched flocked rectal swab/stool pairs, we found no significant difference in pathogen detection rates between the flocked rectal swab samples and traditional bulk stool sampling methods for any bacterial (168 versus 167, respectively), viral (94 versus 92, respectively), or protozoan (18 versus 18, respectively) targets. The combination of flocked rectal swab samples with FilmArray testing allows for the rapid diagnosis of infectious gastroenteritis, facilitating a test-and-treat approach for infections that are life-threatening in many resource-limited settings. The culture recovery rates for bacterial pathogens utilizing this approach need to be assessed.

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Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis
Celia R. Walker, Kwana Lechiile, Margaret Mokomane, Andrew P. Steenhoff, Tonya Arscott-Mills, Jeffrey M. Pernica, David M. Goldfarb
Journal of Clinical Microbiology Nov 2019, 57 (12) e00962-19; DOI: 10.1128/JCM.00962-19

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Evaluation of Anatomically Designed Flocked Rectal Swabs for Use with the BioFire FilmArray Gastrointestinal Panel for Detection of Enteric Pathogens in Children Admitted to Hospital with Severe Gastroenteritis
Celia R. Walker, Kwana Lechiile, Margaret Mokomane, Andrew P. Steenhoff, Tonya Arscott-Mills, Jeffrey M. Pernica, David M. Goldfarb
Journal of Clinical Microbiology Nov 2019, 57 (12) e00962-19; DOI: 10.1128/JCM.00962-19
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KEYWORDS

diarrhea
Shigella
gastroenteritis
rectal swab

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