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Letter to the Editor

Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid

Jerome H. Chin, Abdu K. Musubire, Nicole Morgan, Jacob Pellinen, Scott Grossman, Jaydeep M. Bhatt, Vincent Wadda, Willy Ssengooba
Melissa B. Miller, Editor
Jerome H. Chin
aDepartment of Neurology, NYU Langone Health, New York, New York, USA
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Abdu K. Musubire
cDepartment of Medicine, Makerere University, Kampala, Uganda
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Nicole Morgan
aDepartment of Neurology, NYU Langone Health, New York, New York, USA
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Jacob Pellinen
aDepartment of Neurology, NYU Langone Health, New York, New York, USA
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Scott Grossman
aDepartment of Neurology, NYU Langone Health, New York, New York, USA
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Jaydeep M. Bhatt
aDepartment of Neurology, NYU Langone Health, New York, New York, USA
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Vincent Wadda
cDepartment of Medicine, Makerere University, Kampala, Uganda
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Willy Ssengooba
bDepartment of Medical Microbiology, Makerere University, Kampala, Uganda
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Melissa B. Miller
University of North Carolina School of Medicine
Roles: Editor
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DOI: 10.1128/JCM.00249-19
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Tables

  • TABLE 1

    CSF results of patients with tuberculous meningitis

    PatientHIV infectionCSF contentaAssay result for:MGITb (no. of days to growth)
    Cells (no. of WBC/µl)Lymph (%)Protein (mg/dl)Glucose (mmol/liter)Xpert MTB/RIFXpert MTB/RIF Ultra
    1No100801400.3LowLow7
    2No200851040.9LowLow9
    3No25904231.4Very LowVery LowNG
    4No10851780.9Very LowTrace13
    5Yes350603346.1NDVery LowNG
    6No50903120.8NDTraceNG
    7No25801090.4NDTrace17
    8No4585890.3NDND12
    9No10851103.4NDNDNG
    10Yes220751292.1NDNDNG
    11No100801001.7NDNDNG
    • ↵a WBC, white blood cell; CSF, cerebrospinal fluid; lymph, lymphocyte.

    • ↵b MGIT, mycobacterial growth indicator tube; ND, not detected; NG, no growth at 6 weeks.

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Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid
Jerome H. Chin, Abdu K. Musubire, Nicole Morgan, Jacob Pellinen, Scott Grossman, Jaydeep M. Bhatt, Vincent Wadda, Willy Ssengooba
Journal of Clinical Microbiology May 2019, 57 (6) e00249-19; DOI: 10.1128/JCM.00249-19

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Xpert MTB/RIF Ultra for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid
Jerome H. Chin, Abdu K. Musubire, Nicole Morgan, Jacob Pellinen, Scott Grossman, Jaydeep M. Bhatt, Vincent Wadda, Willy Ssengooba
Journal of Clinical Microbiology May 2019, 57 (6) e00249-19; DOI: 10.1128/JCM.00249-19
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KEYWORDS

cerebrospinal fluid
Mycobacterium tuberculosis
tuberculous meningitis
Xpert MTB/RIF

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