DOI: 10.1128/JCM.01446-19
ABSTRACT
The Clinical and Laboratory Standards Institute antimicrobial and antifungal standards define a susceptible-dose-dependent (SDD) category for certain organisms and drug combinations. Reporting MICs within the SDD category suggests that treatment success is likely with increased drug exposure. These breakpoints are based on pharmacokinetic, pharmacodynamic, and clinical outcome data from adults and not pediatric patients. This commentary aims to discuss the implications of reporting SDD interpretations for pediatric patients and recommends laboratory reporting comments.
The views expressed in this article do not necessarily reflect the views of the journal or of ASM.
FOOTNOTES
- Accepted manuscript posted online 30 October 2019.
Supplemental material is available online only.
- Copyright © 2019 American Society for Microbiology.
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