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Table of Contents

May 2020; Volume 58,Issue 5

Photo Quiz

  • Photo Quiz: A 55-Year-Old-Man with Rectal Bleeding and a Rectal Mass
    Photo Quiz
    Photo Quiz: A 55-Year-Old-Man with Rectal Bleeding and a Rectal Mass
    Yoke Chen Poon, Chiaw Yee Choy, Manish M. Bundele, Sapna P. Sadarangani
  • Answer to May 2020 Photo Quiz
    Photo Quiz
    Answer to May 2020 Photo Quiz
    Yoke Chen Poon, Chiaw Yee Choy, Manish M. Bundele, Sapna P. Sadarangani

Editorials

  • Free
    2020 American Society for Microbiology Awards Program Honorees in Clinical Microbiology
    Editorial
    2020 American Society for Microbiology Awards Program Honorees in Clinical Microbiology
    Erik Munson
  • Free
    What’s Special about Cefiderocol? A Micro-Comic Strip
    Editorial
    What’s Special about Cefiderocol? A Micro-Comic Strip
    Patricia J. Simner, Alexander J. McAdam

The Brief Case

  • Free
    The Brief Case: Mold Infection of an Indwelling Cranial Device—a Perplexing Combination of “Classic” Laboratory Findings
    The Brief Case
    The Brief Case: Mold Infection of an Indwelling Cranial Device—a Perplexing Combination of “Classic” Laboratory Findings
    Melphine M. Harriott, Stephanie K. Carnes, Charles W. Stratton, Patty W. Wright, Jonathan E. Schmitz
  • Free
    Closing the Brief Case: Mold Infection of an Indwelling Cranial Device—a Perplexing Combination of “Classic” Laboratory Findings
    The Brief Case
    Closing the Brief Case: Mold Infection of an Indwelling Cranial Device—a Perplexing Combination of “Classic” Laboratory Findings
    Melphine M. Harriott, Stephanie K. Carnes, Charles W. Stratton, Patty W. Wright, Jonathan E. Schmitz

Minireviews

  • Free
    Emergence of a Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2: Biology and Therapeutic Options
    Minireview
    Emergence of a Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2: Biology and Therapeutic Options

    The new decade of the 21st century (2020) started with the emergence of a novel coronavirus known as SARS-CoV-2 that caused an epidemic of coronavirus disease (COVID-19) in Wuhan, China. It is the third highly pathogenic and transmissible coronavirus after severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in humans. The source of origin, transmission...

    Suliman Khan, Rabeea Siddique, Muhammad Adnan Shereen, Ashaq Ali, Jianbo Liu, Qian Bai, Nadia Bashir, Mengzhou Xue
  • Targeting Asymptomatic Bacteriuria in Antimicrobial Stewardship: the Role of the Microbiology Laboratory
    Minireview
    Targeting Asymptomatic Bacteriuria in Antimicrobial Stewardship: the Role of the Microbiology Laboratory

    This minireview focuses on the microbiologic evaluation of patients with asymptomatic bacteriuria, as well as indications for antibiotic treatment. Asymptomatic bacteriuria is defined as two consecutive voided specimens (preferably within 2 weeks) with the same bacterial species, isolated in quantitative counts of ≥105 CFU/ml in women, including pregnant women; a single voided urine specimen with one bacterial species...

    Zanthia Wiley, Jesse T. Jacob, Eileen M. Burd
  • Pharmacy-Based Infectious Disease Management Programs Incorporating CLIA-Waived Point-of-Care Tests
    Minireview
    Pharmacy-Based Infectious Disease Management Programs Incorporating CLIA-Waived Point-of-Care Tests

    There are roughly 48,000 deaths caused by influenza annually and an estimated 200,000 people who have undiagnosed human immunodeficiency virus (HIV). These are examples of acute and chronic illnesses that can be identified by employing a CLIA-waived test. Pharmacies across the country have been incorporating CLIA-waived point-of-care tests (POCT) into disease screening and management programs offered in the pharmacy. The rationale...

    S. R. Herbin, D. G. Klepser, M. E. Klepser

Bacteriology

  • Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of <span class="named-content genus-species" id="named-content-1">Clostridioides difficile</span> Infection in Patients with Discordant Diagnostic Test Results
    Bacteriology
    Evaluation of Cycle Threshold, Toxin Concentration, and Clinical Characteristics of Clostridioides difficile Infection in Patients with Discordant Diagnostic Test Results

    Clostridioides difficile infection (CDI) is one of the most common health care-associated infections that can cause significant morbidity and mortality. CDI diagnosis involves laboratory testing in conjunction with clinical assessment. The objective of this study was to assess the performance of various C...

    Megan D. Shah, Joan-Miquel Balada-Llasat, Kelci Coe, Erica Reed, Johanna Sandlund, Preeti Pancholi
  • Open Access
    Multicenter Evaluation of the BD Phoenix CPO Detect Test for Detection and Classification of Carbapenemase-Producing Organisms in Clinical Isolates
    Bacteriology
    Multicenter Evaluation of the BD Phoenix CPO Detect Test for Detection and Classification of Carbapenemase-Producing Organisms in Clinical Isolates

    Limited treatment options contribute to high morbidity/mortality rates with carbapenem-resistant, Gram-negative bacterial infections. New approaches for carbapenemase-producing organism (CPO) detection may help inform clinician decision-making on patient treatment and infection control. BD Phoenix CPO detect (CPO detect) detects and classifies carbapenemases in Enterobacterales,...

    Vicki Whitley, Susan Kircher, Tracey Gill, Janet A. Hindler, Susan O’Rourke, Charles Cooper, Anagha Tulpule, Gerald A. Denys
  • Pooling Pharyngeal, Anorectal, and Urogenital Samples for Screening Asymptomatic Men Who Have Sex with Men for <span class="named-content genus-species" id="named-content-1">Chlamydia trachomatis</span> and <span class="named-content genus-species" id="named-content-2">Neisseria gonorrhoeae</span>
    Bacteriology
    Pooling Pharyngeal, Anorectal, and Urogenital Samples for Screening Asymptomatic Men Who Have Sex with Men for Chlamydia trachomatis and Neisseria gonorrhoeae

    Screening for Chlamydia trachomatis and Neisseria gonorrhoeae at the pharyngeal, urogenital, and anorectal sites is recommended for men who have sex with men (MSM). Combining the three individual-site samples into a single pooled sample could result in significant cost savings, provided there is no...

    Duygu Durukan, Tim R. H. Read, Catriona S. Bradshaw, Christopher K. Fairley, Deborah A. Williamson, Vesna De Petra, Kate Maddaford, Rebecca Wigan, Marcus Y. Chen, Anne Tran, Eric P. F. Chow
  • Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing <span class="named-content genus-species" id="named-content-1">Klebsiella michiganensis</span> Outbreak in a Neonatal Unit
    Bacteriology
    Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit

    Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis...

    Paul Chapman, Brian M. Forde, Leah W. Roberts, Haakon Bergh, Debra Vesey, Amy V. Jennison, Susan Moss, David L. Paterson, Scott A. Beatson, Patrick N. A. Harris
  • Evaluation of a Novel Multiplex PCR Panel Compared to Quantitative Bacterial Culture for Diagnosis of Lower Respiratory Tract Infections
    Bacteriology
    Evaluation of a Novel Multiplex PCR Panel Compared to Quantitative Bacterial Culture for Diagnosis of Lower Respiratory Tract Infections

    Quantitative bacterial culture of bronchoalveolar lavage fluids (BALF) is labor-intensive, and the delay involved in performing culture, definitive identification, and susceptibility testing often results in prolonged use of broad-spectrum antibiotics. The Unyvero lower respiratory tract (LRT) panel (Curetis, Holzgerlingen, Germany) allows the multiplexed rapid detection and identification of 20 potential etiologic agents of pneumonia...

    Mackenzie E. Collins, Elena B. Popowitch, Melissa B. Miller
  • High-Content Screening, a Reliable System for <span class="named-content genus-species" id="named-content-1">Coxiella burnetii</span> Isolation from Clinical Samples
    Bacteriology
    High-Content Screening, a Reliable System for Coxiella burnetii Isolation from Clinical Samples

    Q fever, caused by Coxiella burnetii, is a worldwide zoonotic disease that may cause severe forms in humans and requires a specific and prolonged antibiotic treatment. Although current serological and molecular detection tools allow a reliable diagnosis of the disease, culture of C. burnetii strains...

    Rania Francis, Maxime Mioulane, Marion Le Bideau, Marie-Charlotte Mati, Pierre-Edouard Fournier, Didier Raoult, Jacques Yaacoub Bou Khalil, Bernard La Scola

Chlamydiology and Rickettsiology

  • Open Access
    Development of a Sensitive and Rapid Recombinase Polymerase Amplification Assay for Detection of <span class="named-content genus-species" id="named-content-1">Anaplasma phagocytophilum</span>
    Chlamydiology and Rickettsiology
    Development of a Sensitive and Rapid Recombinase Polymerase Amplification Assay for Detection of Anaplasma phagocytophilum

    Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the obligate intracellular Gram-negative bacterium Anaplasma phagocytophilum. The disease often presents with nonspecific symptoms with negative serology during the acute phase. Direct pathogen detection is the best approach for early confirmatory diagnosis. Over the years, PCR-based molecular...

    Le Jiang, Philip Ching, Chien-Chung Chao, J. Stephen Dumler, Wei-Mei Ching

Mycobacteriology and Aerobic Actinomycetes

  • Open Access
    Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay
    Mycobacteriology and Aerobic Actinomycetes
    Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay

    Pyrazinamide (PZA) is considered the pivot drug in all tuberculosis treatment regimens due to its particular action on the persistent forms of Mycobacterium tuberculosis. However, no drug susceptibility test (DST) is considered sufficiently reliable for routine application. Although molecular tests are endorsed, their application is limited to known PZA resistance...

    Roberto Alcántara, Patricia Fuentes, Lisette Marin, Daniela E. Kirwan, Robert H. Gilman, Mirko Zimic, Patricia Sheen
  • Fluorescent Hybridization of <span class="named-content genus-species" id="named-content-1">Mycobacterium leprae</span> in Skin Samples Collected in Burkina Faso
    Mycobacteriology and Aerobic Actinomycetes
    Fluorescent Hybridization of Mycobacterium leprae in Skin Samples Collected in Burkina Faso

    Leprosy is caused by Mycobacterium leprae, and it remains underdiagnosed in Burkina Faso. We investigated the use of fluorescent in situ hybridization (FISH) for detecting M. leprae in 27 skin samples (skin biopsy samples, slit skin samples, and skin lesion swabs) collected from 21 patients...

    Anselme Millogo, Ahmed Loukil, Mustapha Fellag, Boukary Diallo, Abdoul Salam Ouedraogo, Sylvain Godreuil, Michel Drancourt

Mycology

  • Evaluation of ID Fungi Plates Medium for Identification of Molds by MALDI Biotyper
    Mycology
    Evaluation of ID Fungi Plates Medium for Identification of Molds by MALDI Biotyper

    MALDI-TOF mass spectrometry (MS) identification of pathogenic filamentous fungi is often impaired by difficulties in harvesting hyphae embedded in the medium and long extraction protocols. The ID Fungi Plate (IDFP) is a novel culture method developed to address such difficulties and improve the identification of filamentous fungi by MALDI-TOF MS. We cultured 64 strains and 11 clinical samples on IDFP, Sabouraud agar-chloramphenicol (SAB...

    Marie Gladys Robert, Charlotte Romero, Céline Dard, Cécile Garnaud, Odile Cognet, Thomas Girard, Tahinamandranto Rasamoelina, Muriel Cornet, Danièle Maubon
  • Open Access
    Multicenter Evaluation of a PCR-Based Digital Microfluidics and Electrochemical Detection System for the Rapid Identification of 15 Fungal Pathogens Directly from Positive Blood Cultures
    Mycology
    Multicenter Evaluation of a PCR-Based Digital Microfluidics and Electrochemical Detection System for the Rapid Identification of 15 Fungal Pathogens Directly from Positive Blood Cultures

    Routine identification of fungal pathogens from positive blood cultures by culture-based methods can be time-consuming, delaying treatment with appropriate antifungal agents. The GenMark Dx ePlex investigational use only blood culture identification fungal pathogen panel (BCID-FP) rapidly detects 15 fungal targets simultaneously in blood culture samples positive for fungi by Gram staining. We aimed to determine the performance of the...

    Sean X. Zhang, Karen C. Carroll, Shawna Lewis, Marissa Totten, Peter Mead, Linoj Samuel, Lisa L. Steed, Frederick S. Nolte, Adam Thornberg, Jennifer L. Reid, Natalie N. Whitfield, N. Esther Babady

Parasitology

  • Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections
    Parasitology
    Recombinase Polymerase Amplification and Lateral Flow Assay for Ultrasensitive Detection of Low-Density Plasmodium falciparum Infection from Controlled Human Malaria Infection Studies and Naturally Acquired Infections

    Microscopy and rapid diagnostic tests (RDTs) are the main diagnostic tools for malaria but fail to detect low-density parasitemias that are important for maintaining malaria transmission. To complement existing diagnostic methods, an isothermal reverse transcription-recombinase polymerase amplification and lateral flow assay (RT-RPA) was developed. We compared the performance with that of ultrasensitive reverse transcription-...

    Albert Lalremruata, The Trong Nguyen, Matthew B. B. McCall, Ghyslain Mombo-Ngoma, Selidji T. Agnandji, Ayôla A. Adegnika, Bertrand Lell, Michael Ramharter, Stephen L. Hoffman, Peter G. Kremsner, Benjamin Mordmüller

Virology

  • Validation of an Epstein-Barr Virus Antibody Risk Stratification Signature for Nasopharyngeal Carcinoma by Use of Multiplex Serology
    Virology
    Validation of an Epstein-Barr Virus Antibody Risk Stratification Signature for Nasopharyngeal Carcinoma by Use of Multiplex Serology

    Serological testing for nasopharyngeal carcinoma (NPC) has recently been reinvigorated by the implementation of novel Epstein-Barr virus (EBV)-specific IgA and IgG antibodies from a proteome array. Although proteome arrays are well suited for comprehensive antigen selection, they are not applicable for large-scale studies. We adapted a 13-marker EBV antigen signature for NPC risk identified by proteome arrays to multiplex serology to...

    Julia Simon, Zhiwei Liu, Nicole Brenner, Kelly J. Yu, Wan-Lun Hsu, Cheng-Ping Wang, Yin-Chu Chien, Anna E. Coghill, Chien-Jen Chen, Julia Butt, Carla Proietti, Denise L. Doolan, Allan Hildesheim, Tim Waterboer
  • Open Access
    Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens
    Virology
    Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens

    The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with results available in approximately 69 min. The pathogens identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human...

    Amy L. Leber, Jan Gorm Lisby, Glen Hansen, Ryan F. Relich, Uffe Vest Schneider, Paul Granato, Stephen Young, Josep Pareja, Irene Hannet
  • Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated <em>In Vitro</em> and with Clinical Specimens
    Virology
    Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens

    On 31 December 2019, the World Health Organization was informed of a cluster of cases of pneumonia of unknown etiology in Wuhan, China. Subsequent investigations identified a novel coronavirus, now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from the affected patients. Highly sensitive and specific laboratory diagnostics are important for controlling the rapidly evolving SARS-CoV-2-associated coronavirus disease...

    Jasper Fuk-Woo Chan, Cyril Chik-Yan Yip, Kelvin Kai-Wang To, Tommy Hing-Cheung Tang, Sally Cheuk-Ying Wong, Kit-Hang Leung, Agnes Yim-Fong Fung, Anthony Chin-Ki Ng, Zijiao Zou, Hoi-Wah Tsoi, Garnet Kwan-Yue Choi, Anthony Raymond Tam, Vincent Chi-Chung Cheng, Kwok-Hung Chan, Owen Tak-Yin Tsang, Kwok-Yung Yuen
  • Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid
    Virology
    Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid

    Human herpesvirus 6 (HHV-6) is an important cause of meningitis and meningoencephalitis. As testing for HHV-6 in cerebrospinal fluid (CSF) is more readily available using the FilmArray Meningitis/Encephalitis panel (FA-ME; BioFire Diagnostics, Salt Lake City, UT), we aimed to determine the clinical significance of detecting HHV-6 in order to identify true infections and to ensure appropriate antiviral initiation. Chart review on 25...

    Utsav Pandey, Alexander L. Greninger, Greg R. Levin, Keith R. Jerome, Vikram C. Anand, Jennifer Dien Bard
  • Nanopore Sequencing Reveals Novel Targets for Detection and Surveillance of Human and Avian Influenza A Viruses
    Virology
    Nanopore Sequencing Reveals Novel Targets for Detection and Surveillance of Human and Avian Influenza A Viruses

    Accurate detection of influenza A virus (IAV) is crucial for patient management, infection control, and epidemiological surveillance. The World Health Organization and the Centers for Disease Control and Prevention have recommended using the M gene as the diagnostic gene target for reverse-transcription-PCR (RT-PCR). However, M gene RT-PCR has reduced sensitivity for recent IAV due to novel gene mutations. Here, we sought to identify...

    Cyril Chik-Yan Yip, Wan-Mui Chan, Jonathan Daniel Ip, Claudia Win-May Seng, Kit-Hang Leung, Rosana Wing-Shan Poon, Anthony Chin-Ki Ng, Wai-Lan Wu, Hanjun Zhao, Kwok-Hung Chan, Gilman Kit-Hang Siu, Timothy Ting-Leung Ng, Vincent Chi-Chung Cheng, Kin-Hang Kok, Kwok-Yung Yuen, Kelvin Kai-Wang To

Immunoassays

  • Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Infections Based on Biofilm Antigens
    Immunoassays
    Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic Staphylococcus aureus Infections Based on Biofilm Antigens

    Prosthetic joint infections are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Pathogen identification relies on microbial culture that requires days to weeks, and in the case of chronic biofilm infections, lacks sensitivity. Diagnosis of infection is often delayed past the point of effective treatment such that only the removal of the implant is curative. Early diagnosis of an infection based on...

    Janette M. Harro, Mark E. Shirtliff, William Arnold, Jennifer M. Kofonow, Chad Dammling, Yvonne Achermann, Kristen Brao, Javad Parvizi, Jeff G. Leid
  • A Fully Automated Multiplex Assay for Diagnosis of Lyme Disease with High Specificity and Improved Early Sensitivity
    Immunoassays
    A Fully Automated Multiplex Assay for Diagnosis of Lyme Disease with High Specificity and Improved Early Sensitivity

    Lyme borreliosis is a tick-borne disease caused by the Borrelia burgdorferi sensu lato complex. Bio-Rad Laboratories has developed a fully automated multiplex bead-based assay for the detection of IgM and IgG antibodies to B. burgdorferi. The BioPlex 2200 Lyme Total assay exhibits an...

    Johnnie B. Hahm, John W. Breneman, Jing Liu, Svetlana Rabkina, Weiming Zheng, Shuxia Zhou, Roger P. Walker, Ravi Kaul

Clinical Veterinary Microbiology

  • Differentiation of Community-Associated and Livestock-Associated Methicillin-Resistant <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Isolates and Identification of <em>spa</em> Types by Use of PCR and High-Resolution Melt Curve Analysis
    Clinical Veterinary Microbiology
    Differentiation of Community-Associated and Livestock-Associated Methicillin-Resistant Staphylococcus aureus Isolates and Identification of spa Types by Use of PCR and High-Resolution Melt Curve Analysis

    Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are present worldwide and represent a major public health concern. The capability of PCR followed by high-resolution melt (HRM) curve analysis for the detection of community-associated and livestock-associated MRSA strains and the identification of staphylococcal protein A (spa) locus was...

    Seyed A. Ghorashi, Jane Heller, Quincy Zhang, Shafi Sahibzada

Epidemiology

  • Fourier Transform Infrared Spectroscopy Is a New Option for Outbreak Investigation: a Retrospective Analysis of an Extended-Spectrum-Beta-Lactamase-Producing <span class="named-content genus-species" id="named-content-1">Klebsiella pneumoniae</span> Outbreak in a Neonatal Intensive Care Unit
    Epidemiology
    Fourier Transform Infrared Spectroscopy Is a New Option for Outbreak Investigation: a Retrospective Analysis of an Extended-Spectrum-Beta-Lactamase-Producing Klebsiella pneumoniae Outbreak in a Neonatal Intensive Care Unit

    The IR Biotyper is a new automated typing system based on Fourier-transform infrared (FT-IR) spectroscopy that gives results within 4 h. We aimed (i) to use the IR Biotyper to retrospectively analyze an outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) in a neonatal intensive care unit and to compare results to BOX-PCR and whole-...

    Nadya Rakovitsky, Sammy Frenk, Hadas Kon, David Schwartz, Elizabeth Temkin, Ester Solter, Svetlana Paikin, Regev Cohen, Mitchell J. Schwaber, Yehuda Carmeli, Jonathan Lellouche
  • Impact of Changes in Clinical Microbiology Laboratory Location and Ownership on the Practice of Infectious Diseases
    Epidemiology
    Impact of Changes in Clinical Microbiology Laboratory Location and Ownership on the Practice of Infectious Diseases

    The number of onsite clinical microbiology laboratories in hospitals is decreasing, likely related to the business model for laboratory consolidation and labor shortages, and this impacts a variety of clinical practices, including that of banking isolates for clinical or epidemiologic purposes. To determine the impact of these trends, infectious disease (ID) physicians were surveyed regarding their perceptions of offsite services....

    Michael Pentella, Melvin P. Weinstein, Susan E. Beekmann, Philip M. Polgreen, Richard T. Ellison

Letters to the Editor

  • Free
    Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
    Letter to the Editor
    Negative Nasopharyngeal and Oropharyngeal Swabs Do Not Rule Out COVID-19
    Poramed Winichakoon, Romanee Chaiwarith, Chalerm Liwsrisakun, Parichat Salee, Aree Goonna, Atikun Limsukon, Quanhathai Kaewpoowat
  • Fecal Shedding of Bovine Astrovirus CH13/NeuroS1 in Veal Calves
    Letter to the Editor
    Fecal Shedding of Bovine Astrovirus CH13/NeuroS1 in Veal Calves
    Ronja V. Kauer, Michel C. Koch, Lutz Schönecker, Jens Becker, Melle Holwerda, Anna N. Glaus, Melanie M. Hierweger, Simea Werder, Ronald Dijkman, Mireille Meylan, Torsten Seuberlich

Masthead

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    Editorial Board
    Masthead
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Journal of Clinical Microbiology: 58 (5)

In This Issue

volume 58, issue 5
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  • Photo Quiz
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  • The Brief Case
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  • Bacteriology
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  • Laboratory Diagnosis of COVID-19: Current Issues and Challenges
  • When To Retest: an Examination of Repeat COVID-19 PCR Patterns in an Ambulatory Population
  • Performance of Abbott ID Now COVID-19 Rapid Nucleic Acid Amplification Test Using Nasopharyngeal Swabs Transported in Viral Transport Media and Dry Nasal Swabs in a New York City Academic Institution
  • Clinical Evaluation of BD Veritor SARS-CoV-2 Point-of-Care Test Performance Compared to PCR-Based Testing and versus the Sofia 2 SARS Antigen Point-of-Care Test
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