ABSTRACT
The SuperCAZ/AVI medium was developed for screening ceftazidime-avibactam (CZA) resistance among Gram-negative bacteria (Enterobacterales and Pseudomonas aeruginosa). It was evaluated using 50 CZA-susceptible and 42 CZA-resistant Gram-negative isolates. Its sensitivity and specificity of detection were 100%. Excellent performance of the medium was also observed by testing spiked stools, with the lower limit of detection ranging from 101 to 102 CFU/ml. This screening medium provides the opportunity to detect CZA-resistant isolates regardless of their resistance mechanisms.
FOOTNOTES
- Received 1 May 2020.
- Returned for modification 28 May 2020.
- Accepted 16 June 2020.
- Accepted manuscript posted online 24 June 2020.
[This article was published on 24 August 2020 with a CC BY 4.0 copyright line (“Copyright © 2020 Sadek et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.”). The authors elected to remove open access for the article after publication, necessitating replacement of the original copyright line, and this change was made on 29 September 2020.]
- Copyright © 2020 American Society for Microbiology.
