TABLE 5.

Estimated specificities of endocervical diagnostic tests for C. trachomatis stratified by subjects' characteristics

Characteristics of subjects tested% Specificity (95% CI)a for cervical test type:
PACE2LCRPCR
Culture-PCRCulture-LCRCulture-PCRCulture-LCR
All subjects99.7 (99.5, 99.9)99.7 (99.5, 99.9)99.3 (98.9, 99.8)99.7 (99.6, 99.9)
Age (yr)
    <20100 (99.5, 100)b100 (99.4, 100)b98.9 (98.0, 99.9)99.8 (99.4, 100)
    ≥2099.6 (99.4, 99.9)99.6 (99.4, 99.9)99.4 (99.0, 99.8)99.7 (99.5, 99.9)
Mucopurulent endocervical discharge
    Present100.0 (99.1, 100)100.0 (99.1, 100)98.1 (96.9, 99.4)c99.7 (98.7, 100)
    Absent99.6 (99.3, 99.9)99.6 (99.3, 99.9)99.5 (99.1, 99.8)99.8 (99.6, 100)
Current menses
    Yes99.5 (98.6, 100)99.5 (98.6, 100)99.5 (98.6, 100)99.5 (98.6, 100)
    No99.7 (99.5, 99.9)99.7 (99.5, 99.9)99.3 (98.8, 99.8)99.7 (99.6, 99.9)
N. gonorrhoeae detected at cervix
    Yes99.2 (97.9, 100)99.2 (97.7, 100)97.0 (94.1, 99.9)100.0 (97.6, 100)
    No99.8 (99.5, 100)99.8 (99.5, 100)99.3 (98.9, 99.7)99.8 (99.5, 100)
Hematuria
    Yes99.5 (99.1, 100)99.5 (99.1, 100)99.4 (98.9, 99.9)100.0 (99.6, 100)c
    No99.7 (99.5, 100)99.7 (99.5, 100)99.4 (99.0, 99.9)99.7 (99.4, 99.9)
Urine leukocyte esterase
    Positive99.8 (99.5, 100)99.8 (99.5, 100)99.3 (98.8, 99.8)99.9 (99.7, 100)
    Negative99.7 (99.4, 100)99.7 (99.4, 100)99.4 (98.8, 99.9)99.7 (99.3, 100)
  • a Adjusted for variation in test performance across centers. Performance is defined as described in the text using two reference standards (culture-PCR and culture-LCR); estimates are reported separately for each. CI, confidence interval.

  • b P = 0.04 for comparison of test specificities in the presence versus absence of subject characteristic noted.

  • c P = 0.05 for comparison of test specificities in the presence versus absence of subject characteristic noted.