TABLE 6.

Estimated sensitivities of C. trachomatis diagnostic tests performed on urine, stratified by subjects' characteristics

Characteristics of subjects tested% Sensitivity (95% CI)a for urine test type
LCRbPCRc
All subjects78.3 (71.4, 85.2)74.0 (62.2, 85.8)
Age (yr)
    <2080.2 (72.0, 88.4)72.9 (63.9, 81.8)
    ≥2076.5 (64.3, 88.7)73.8 (60.1, 87.4)
Mucopurulent endocervical discharge
    Present85.9 (72.7, 99.0)78.4 (67.5, 89.4)
    Absent73.8 (69.0, 78.6)72.2 (59.5, 84.8)
Dysuria
    Present88.9 (77.7, 100)77.5 (55.1, 99.9)
    Absent77.9 (70.9, 85.0)73.8 (61.6, 85.9)
Hematuriad
    Yes84.4 (74.0, 94.7)80.9 (64.6, 97.3)
    No76.9 (70.7, 83.1)69.6 (60.7, 78.6)
Urine leukocyte esterase positive
    Yes86.3 (79.1, 93.4)e81.5 (71.0, 91.9)f
    No69.7 (62.2, 77.2)61.5 (49.2, 73.8)
  • a Adjusted for variation in test performance across centers. Performance is defined as described in the text using two reference standards (culture-PCR and culture-LCR); estimates are reported separately for each. CI, confidence interval.

  • b Reference standard was culture-PCR (positive results by culture or PCR).

  • c Reference standard was culture-LCR (positive results by culture or LCR).

  • d Defined as presence of blood on urine dipstick test.

  • e P = 0.002 for comparison of test sensitivities in the presence versus absence of subject characteristic noted.

  • f P = 0.02 for comparison of test sensitivities in the presence versus absence of subject characteristic noted.