TABLE 1.

Results of typing of 188 H. influenzae strains isolated from 30 patients with CF at three different hospitals in Spaina

Patient no.SexbPatient age at isolate collection (yr/mo)Sampling period (mo)No. of H. influenzae strainscPFGE pattern(s)dStrain distribution according to PFGE pattern(s)Persistence of PFGE pattern (mo)OMP variant(s)Biotype(s) (no. of strains)
1M37/1080151A, 1B, 210, 4, 180, 15, 01Aa, 1Ab, 1AcVI (6)-VIII (2)-VII (2) VI, VI
2F18/113933, 42, 139, 0VII, V
3F12/441185, 6, 7, 814, 2, 1, 126, 10, 0, 05a(5), 5b, 5c(4), 6aV, III, II, III
4M4/35879, 10, 11, 12, 131, 2, 1, 1, 20, 3, 0, 0, 2II, I, I, II, I
5M15/960314, 152, 11, 0II, III
6F3/10611516, NT, 17, 18, 19, 20, 21, 22, 23, 24, 25, 262, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 33, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 8II, VII, II, I, IV, III, II, III, I, III, III, I
7F4/11771527, 28, 19, 29, 30, 31, 32, 33, 34, 35, 36, 37, 382, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1<1, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 019aI, I, II, II, V, III, III, II, II, III, II, II, II
8M11/241339, 40, 411, 1, 1II, II, II
9M21/512341, 42, 431, 1, 1III, III, II
10F16/849244, 451, 1I, II
11M11/948346, 47, 481, 1, 1II, II, I
12M1/637649, 41a, 50, 51, 52, 531, 1, 1, 1, 1, 141aVIII, II, VII, III, II, II
13M5/951552a, 54, 55, 561, 2, 1, 10, 1, 0, 052aII, III, II, II
14F8/11331391II
15M18/1501571I
16F6/7411521VIII
17F5/1048758, 59, 60, 61, 622, 1, 1, 1, 29, 0, 0, 0, 6II, V, I, III, II
18M4/1040463, 64, NT, 651, 1, 1, 1I, II, III, I
19M22/628266, 671, 1IV, III
20F3/838968, 69, 70, 71, 72, 731, 2, 2, 1, 2, 10, 11, 1, 0, 2, 072aIII, II, I, V, III, II
21M1/247774, 75, 76, 77, 78, 79, 701, 1, 1, 1, 1, 1, 1I, III, V, III, II, II, I
22F5/816580, 81, 82, 831, 1, 1, 20, 0, 0, 283aII, II, II, VII, II
23M2/340784, 85, 86, 87, 88, 891, 2, 1, 1, 1, 10, 2, 0, 0, 0, 0III, II, III, II, II, I
24M20/219290, 911, 1III, III
25M317292, 931, 1II, III
26M9/723394, 95, 961, 1, 1II, II, II
27M5/6145NT, 97, 98, 99, 1001, 1, 1, 1, 1III, V, II, II, III
28M20/97227101, 102, 103, 104, 10523, 1, 1, 1, 172, 0, 0, 0, 0101aI (20)-II (2)-IV (1), I, I, I, II
29M2/5253106, 107, 1081, 1, 1VII, VI, I
30M6/5204109, 110, 1112, 1, 111, 0, 0I, I, I
  • a 1A and 1B represent clone 1 subtypes. Lower case letters represent OMP variants. Boldface type represents cross-colonizing strains.

  • b M, male; F, female.

  • c Total number of isolates.

  • d NT, nontypeable.