TABLE 4.

Estimated sensitivity of endocervical diagnostic tests for C. trachomatis stratified by subjects' characteristics

Characteristics of subjects tested% Sensitivity (95% CI)a for cervical test type:
PACE2LCRPCR
Culture-PCRCulture-LCRCulture-PCRCulture-LCR
All subjects60.5 (53.9, 67.0)60.2 (50.5, 69.8)83.5 (80.2, 86.8)74.7 (70.8, 78.5)
Age (yr)
    <2066.3 (59.6, 73.1)65.8 (57.7, 73.9)88.9 (84.5, 93.4)78.9 (70.5, 87.3)
    ≥2056.3 (46.2, 66.3)55.0 (43.5, 66.6)79.8 (71.1, 88.4)71.6 (66.5, 76.7)
Mucopurulent endocervical discharge
    Present72.6 (55.3, 89.9)70.2 (56.3, 84.0)87.5 (75.7, 99.4)83.9 (77.2, 90.6)c
    Absent56.0 (48.4, 63.6)56.0 (44.9, 67.2)80.9 (73.6, 88.2)71.1 (65.4, 76.7)
Current menses
    Yes60.7 (34.0, 87.5)60.4 (33.6, 87.2)87.1 (73.0, 100)74.3 (59.4, 89.1)
    No60.3 (55.2, 65.4)60.0 (50.7, 69.3)83.1 (78.9, 87.3)74.7 (70.5, 78.8)
N. gonorrhoeae detected at cervix
    Yes66.4 (47.9, 84.9)62.2 (41.4, 83.0)91.2 (83.4, 98.9)b76.8 (66.7, 86.9)
    No59.2 (51.5, 66.9)58.3 (46.2, 70.4)81.0 (74.5, 87.4)71.3 (66.1, 76.6)
Hematuria
    Yes67.0 (56.6, 77.4)66.0 (53.3, 78.8)88.8 (81.8, 95.7)81.5 (73.4, 89.7)b
    No55.7 (46.7, 64.7)54.4 (44.8, 63.9)81.6 (76.1, 87.2)70.9 (65.5, 76.2)
Urine leukocyte esterase
    Positive63.2 (57.2, 69.3)61.7 (55.5, 67.9)85.5 (81.0, 89.9)79.6 (74.4, 84.8)b
    Negative57.0 (48.9, 65.2)55.3 (42.6, 67.9)81.7 (75.3, 88.1)66.2 (54.1, 78.2)
  • a Adjusted for variation in test performance across centers. Performance was defined as described in the text using two reference standards (culture-PCR and culture-LCR); estimates are reported separately for each. CI, confidence interval.

  • b P = 0.05 for comparison of test sensitivities in the presence versus absence of subject characteristic noted.

  • c P = 0.004 for comparison of test sensitivities in the presence versus absence of subject characteristic noted.