TABLE 2.

In vitro susceptibilities of Candida isolates to amphotericin B, flucytosine, fluconazole, and itraconazole

Species (no. of isolates)Antifungal agentMIC (μg/ml)No. (%) of resistant isolatesa
RangeMIC50MIC90
Candida albicans (423)Amphotericin B0.002-0.50.1250.25NA
Flucytosine≤0.125->64≤0.125118 (4.3)
Fluconazole≤0.125->64≤0.1250.55 (1.2)
Itraconazole≤0.015->80.030.1254 (0.9)
Candida glabrata (226)Amphotericin B0.002-120.250.5NA
Flucytosine≤0.125->8≤0.125≤0.1250
Fluconazole≤0.125->6441616 (7.1)
Itraconazole≤0.015->80.25144 (19.5)
Candida parapsilosis (123)Amphotericin B0.006-1.50.250.38NA
Flucytosine≤0.125->64≤0.125≤0.1251 (<1)
Fluconazole≤0.125->40.510
Itraconazole≤0.015->10.060.251 (<1)
Candida tropicalis (118)Amphotericin B0.006-10.250.38NA
Flucytosine≤0.125->640.250.51 (<1)
Fluconazole≤0.125->640.587 (6)
Itraconazole≤0.015->80.1250.57 (6)
Candida krusei (20)Amphotericin B0.125-40.752NA
Flucytosine2-32881 (5)
Fluconazole2->6432647 (35)
Itraconazole0.125->10.2515 (25)
Candida dubliniensis (8)Amphotericin B0.047-0.250.0640.25NA
Flucytosine≤0.125≤0.125≤0.1250
Fluconazole≤0.125≤0.125≤0.1250
Itraconazole≤0.015-0.250.030.060
Candida lusitaniae (15)Amphotericin B0.002-10.1250.25NA
Flucytosine≤0.125->64≤0.125161 (6.7)
Fluconazole≤0.125-10.510
Itraconazole≤0.015-0.50.060.250
Other Candida speciesb (2)Amphotericin B0.064-0.250.0640.25NA
Flucytosine≤0.125≤0.125≤0.1250
Fluconazole1110
Itraconazole0.06-0.250.060.250
All Candida species (935)Amphotericin B0.002-120.190.38NA
Flucytosine≤0.125->64≤0.125122 (2.4)
Fluconazole≤0.125->640.5835 (3.7)
Itraconazole≤0.015-80.060.561 (6.5)
  • a According to NCCLS breakpoints; no breakpoints have been established for amphotericin B.

  • b Candida kefyr (n = 1) and Candida rugosa (n = 1).