TABLE 1.

Demographic data, cocolonizing organisms, and characteristics of S. pneumoniae isolates from CF patients followed at Ramón y Cajal University Hospital in Madrid, Spain

Patient (gender)Age (yrs)Exacerbation (bacterial count)aCocolonization organism(s)bIsolateMo/yr of isolationPFGE pulsotypeSerotypecAntimicrobial resistance phenotyped
1 (M)4Yes (2 × 107)02250704/1995AA-137
2 (F)NAeNA (9 × 106)Sa04343306/1995R9VPen, SxT
3 (M)NANA (2 × 105)05311607/1995A-423FPen, Ery, Tet, SxT, Clo
4 (F)11No (5 × 105)Sa, Ax09848910/1995A-423FPen, Ctx, Ery, Tet, SxT, Clo
5 (M)NANA (2 × 104)07035606/1996A-523FPen, SxT, Clo
6 (F)5No (9 × 105)08003407/1998G19FTet, SxT
7 (M)2No (1 × 105)Hi05343703/1999B23FPen, Ctx, Tet, SxT, Clo
8 (M)NANA (3 × 106)11100711/1999ACNTPen, Ery, Tet, SxT
9 (M)NANA (2 × 105)05607802/2000O6BClo
10 (M)6No (5 × 103)Hi06592204/2000C23F
11 (F)2No (7 × 105)07644906/2000H19FEry, Tet, Clo
12 (F)3No (1 × 107)Pa, Hi06398603/2001J19FPen, Ery, Tet, SxT
13 (F)11No (1 × 106)Asp, Hi11388111/2001L3
14 (M)9Yes (5 × 107)Sa, Asp08216008/1996N6BTet, SxT, Clo
No (4 × 106)Pa, Asp08720709/2000AA37
15 (M)5No (4 × 103)05274002/1997K3
No (1 × 105)Sa10734712/1999U14
16 (F)8No (1 × 106)Sa05319902/2000M6A
No (4 × 105)Hi07552806/2000M-16A
17 (M)1Yes (3 × 105)05676102/2001I19FPen, Ery, Tet, SxT, Clo
No (3 × 104)05989103/2001I-119FPen, Ery, Tet, SxT
18 (F)12No (2 × 103)Pa, Hi02639101/2002Q7
Yes (1 × 108)Pa, Sa02249401/2003ABNTPen, Ctx, Ery, Tet, SxT, Clo
19 (M)10No (ND)Sa, Asp11509710/2002P6BPen, Ctx, Ery, Tet
No (2 × 106)Sa02468901/2003A-123FPen, Ctx, Ery, Tet, SxT, Clo
20 (F)3No (5 × 108)Pa, Hi01795803/1995A-423FPen, Ctx, Ery, Tet, SxT, Clo
No (8 × 107)Sa, Hi03260505/1995A-423FPen, Ctx, Ery, Tet, SxT, Clo
Yes (6 × 107)Sa, Hi09834710/1995A-423FPen, Ctx, Ery, Tet, SxT, Clo
21 (M)4No (1 × 107)Sa, Hi02052003/1995D19FPen, Ery, Tet, SxT, Clo
No (3 × 104)09384211/1996X23B
No (7 × 105)Hi04980001/1997Z31
22 (F)4NA (4 × 105)04693206/1995Y24
NA (6 × 105)Sa, Hi06648605/1996S11SxT
NA (2 × 107)05004501/1998AD6APen, Ctx, Ery, Tet, SxT, Clo
23 (M)3No (ND)Pa03274001/1998A-223FPen, Ctx, Ery, Tet, SxT, Clo
No (1 × 105)Pa, Sa05707503/1998T14Pen, Ctx, Ery, SxT
No (9 × 105)Pa05948002/2001A-323FPen, Ctx, Tet, SxT, Clo
24 (M)2No (3 × 107)Pa, Ax08334607/1997W19ASxT
No (7 × 105)Hi05237602/1998F19FPen, Ery, Tet, SxT, Clo
No (2 × 106)08164307/1998A23FPen, Ctx, Tet, SxT, Clo
25 (M)7Yes (1 × 108)Sa, Hi03615205/1995E19FTet, SxT, Clo
Yes (3 × 108)11193911/1995AE22Pen, SxT, Clo
Yes (1 × 107)09583810/1997V15B
Yes (4 × 107)05433501/2001AF19F
26 (M)<1Yes (2 × 107)07535707/1996A-523FPen, Ctx, Tet, SxT, Clo
Yes (5 × 105)Pa, Sa09217010/1996A23FPen, Tet, SxT, Clo
Yes (7 × 105)Pa, Sa09388411/1996A23FPen, Tet, SxT, Clo
No (4 × 105)Hi10511812/2000A-323FPen, Ctx, Ery, Tet, SxT, Clo
  • a Number of CFU per milliliter of sputum. ND, not done.

  • b Sa, S. aureus; Ax, A. xylosoxydans; Hi, H. infuenzae; Pa, P. aeruginosa; Asp, Aspergillus spp.

  • c NT, nontypeable.

  • d Pen, penicillin; SxT, trimethoprim-sulfametoxazole; Ery, erythromycin; Tet, tetracycline, Clo, chloramphenicol; Ctx, cefotaxime.

  • e NA, not available.