TABLE 1.

Demographic, radiological, and microbiological data of patients suffering from aspergillosis

PatientGenderUnderlying conditionaAspergillosis diagnosisProphylaxisHRCTGMPCR resulteDays before HRCTfDays before GMg
1MaleALLProvenbFluconazole/itraconazolePositivePositivePositive6765
2MaleNHLProbableNonePositivePositivePositive00
3FemaleAMLProbableItraconazolePositivePositivePositive−27−28
4FemaleAMLProbableItraconazolePositivePositivePositive61199
5FemaleMMProbableFluconazoleNegativecPositivePositive00
6MaleAMLProbableItraconazolePositivePositivePositive137
7MaleALLProbableItraconazolePositiveNegativedPositive8479
8FemaleAMLProbableItraconazolePositivePositivePositive19107
9MaleALLProbableItraconazolePositivePositivePositive90154
10FemaleAMLProbableItraconazolePositivePositiveNegativeNChNC
11MaleMDSPossibleItraconazolePositiveNegativePositive−69NC
12MaleAMLPossibleItraconazolePositiveNegativePositive8NC
  • a ALL, acute lymphoblastic leukemia; NHL, non-Hodgkin's lymphoma; AML, acute myeloblastic leukemia; MM, multiple myeloma; MDS, myelodysplasic syndrome.

  • b Proven aspergillosis by positive culture from tissue biopsies.

  • c Patient was diagnosed with sinonasal aspergillosis after imaging showing sinusitis.

  • d Patient was diagnosed by sputum culture with A. fumigatus.

  • e The table includes analysis taking into account only two or more positive PCR results.

  • f Time in days taken by the PCR-based technique to detect Aspergillus DNA before signs appeared on HRCT; a minus sign indicates that fungal DNA was detected later than signs on the HRCT.

  • g Time in days taken by the PCR-based technique to detect Aspergillus DNA before the GM test was positive; a minus sign indicates that fungal DNA was detected after the GM test was positive. For patient 7, the calculation was made using the date the sputum culture was positive.

  • h NC, not calculated. Values were not calculated because the test was negative.