TABLE 2.

Relationship between bacterial load and clinical features in 81 patients with PCR-confirmed scrub typhusa

VariableAssociation with bacterial loadValueb for indicated no. of DNA copies/mlP
ρcP<100 (n = 18)100-1,000 (n = 44)>1,000 (n = 19)
Admission characteristics
    No. of males (%)NS10 (55.6)26 (59.1)14 (73.7)NS
    Age (yr)0.22§0.0535 (33-47)42 (28-54)48 (37-58)NS
    No. of patients with eschars (%)NS010 (22.7)1 (5.3)0.03
    Duration of symptoms (days)0.16§NS5.5 (4.5-8.0)7.0 (4.5-10.0)8.0 (7.0-11.0)NS
    Hemoglobin concn (mg/dl)−0.03§NS11.8 (11.1-13.6)13.5 (11.3-14.3)12.5 (10.2-13.8)NS
    Platelet count (109/ml)0.24§0.03168 (147-239)184 (135-243)145 (121-213)NS
    White cell count (103/ml)−0.17NS10.1 (7.1-12.9)11.1 (8.5-14.3)11.7 (9.9-13.5)NS
    Serum bicarbonate concn (mmol/liter)−0.300.0126 (24-29)23 (21-26)22 (15-25)0.01
    Blood urea nitrogen concn (mg/dl)0.16§NS13 (12-19)15 (9-19)18 (9-48)NS
    Serum creatinine concn (mg/dl)−0.37§<0.0011.0 (1.0-1.3)1.1 (1.0-1.3)1.5 (1.1-3.4)0.002
    Total serum bilirubin concn (μmol/liter)0.310.010.7 (0.5-1.0)0.7 (0.6-1.5)1.4 (0.7-3.7)0.02
    Direct serum bilirubin concn (μmol/liter)0.290.010.4 (0.3-0.7)0.4 (0.3-0.8)0.9 (0.5-2.7)0.02
    Aspartate aminotransferase concn (U/liter)0.36§0.001106 (73-145)129 (89-172)182 (97-226)0.02
    Alanine aminotransferase concn (U/liter)0.290.0166 (49-99)98 (74-136)142 (76-182)0.04
    Alkaline phosphatase concn (U/liter)0.27§0.02165 (97-275)199 (135-317)324 (196-396)0.04
    APACHE II score0.28§0.014 (3-7)6 (4-9)10 (3-16)0.04
Outcome
    No. of deaths (%)<0.001003 (15.8)0.02
    Fever clearance time (h)0.06NS48 (19-74)48 (20-145)65 (30-136)NS
  • a The default tests for columns 3 and 7 are Spearman's rho (ρ) and the Kruskal-Wallis test, respectively, unless otherwise indicated by superscript symbols as follows: †, t test; ¶, Fisher's exact test. NS, not significant.

  • b Values with ranges in parentheses are medians (IQRs), and other values are quantities (percentages).

  • c §, Pearson's correlation coefficient (R).