TABLE 3.

In vitro susceptibilities of 46 fluconazole- and itraconazole-resistant isolates of C. glabrata to six antifungal agentsa

Antifungal agentNo. of strains for which MIC (μg/ml) was:
0.030.060.120.250.51248163264
Amphotericin B1161910
Flucytosine21241
Posaconazole11188414
Ravuconazole131021101
Voriconazole1516204
Caspofunginb222121
  • a All isolates tested by NCCLS M27-A2 broth microdilution methods (18) or by Etest (amphotericin B). Fluconazole (MIC ≥ 64 μg/ml) and itraconazole (MIC ≥1 μg/ml) resistance defined according to NCCLS M27-A2 guidelines (18).

  • b Caspofungin MICs read as the lowest concentration at which prominent inhibition (∼50%) is observed at 24 h of incubation (Pfaller et al., submitted).