TABLE 4.

Mean signal/cutoff ratios for clinical samples with discordant results between the GP5+/6+ and the MGP PCR systemsf

HPV typeNo. of GP+/MGP samplesMean ratio for GP+ samplesHistopathology/cytology result for GP+/MGP samplesNo. of GP/MGP+ samplesMean ratio for MGP+ samplesHistopathology/cytology result(s) for GP/MGP+ samplesSignificanceaTotal no. of discordant results
162 (0g)1.1NA12 (2b,g)6.2 (14.5h)Condyloma,b benignP < 0.00514
1800NA10 (0)1.5NAP < 0.0510
311 (0)1.3NA17 (1)3.4 (18.8)CIN IIIP < 0.0518
3300NA6 (0)1.9NAP < 0.056
3500NA2 (2c)2.8 (2.2)Two CIN IIcNS2
35v00NA5 (1c)1.6 (1.6)CIN IIcP < 0.055
3900NA14 (2c)2.9 (4.2)Benign, CIN IIcP < 0.00514
4500NA16 (1)4.6 (8.4)BenignP < 0.000516
511 (0)1.0NA31 (7b,d)8.5 (11.6)Benign, condyloma,b atypia, CIN I,d CIN II, CIN NOS, CIN IIIP < 0.000532
5200NA47 (3e)51.2 (115)ASCUS, CIN I, cancereP < 0.000547
561 (1)88.1 (88.1h)CIN I18 (4)3.7 (4.7)Two benign, condyloma, CIN IP < 0.00519
5800NA16 (1e)3.6 (6.7)CancereP < 0.000516
5900NA1 (0)3.14NANS1
661 (0)1.2NA3 (0)2.4NANS4
683 (0)1.3NA3 (1)4.8 (8.3)BenignNS6
61 (0)1.3NA4 (0)2.2NANS5
1100NA1 (0)2.0NANS1
4200NA15 (2d)2.4 (1.7)Benign, CIN IdP < 0.00515
4300NA6 (2)1.6 (1.3)Benign, ASCUSP < 0.056
7000NA9 (1)8.4 (1.2)CIN IP < 0.059
732 (0)1.2NA1 (1)1.0 (1.0)BenignNS3
821 (0)1.2NA3 (1)1.7 (2.0)CIN IIINS4
Total13 (1)NANA240 (27)NANANA253
  • a Wilcoxon signed-rank test for analysis of signal ratios. NS, P > 0.05.

  • b One sample is MGP positive for the HPV-16 and -51 probes.

  • c One sample is MGP positive for the HPV-35, -35v, and -39 probes.

  • d One sample is MGP positive for the HPV-42 and -51 probes.

  • e One sample is MGP positive for the HPV-52 and -58 probes.

  • f NA, not applicable; CIN NOS, CIN, no other specification.

  • g Values in parentheses in this column are the numbers of samples that were negative for all HPV types by the other method.

  • h Values in parentheses in this column are the means of signal/cutoff ratios for samples that were negative for all HPV types by the other method.